27 Result(s)

Article

The miR-29 family facilitates the activation of NK-cell immune responses by targeting the B7-H3 immune checkpoint in neuroblastoma

Neuroblastoma (NB) is a highly aggressive pediatric cancer that originates from immature nerve cells, presenting significant treatment challenges due to therapy resistance. Despite intensive treatment, approxi...

Anup S. Pathania, Haritha Chava, Nagendra K. Chaturvedi… in Cell Death & Disease (2024)

Article

The single-cell opioid responses in the context of HIV (SCORCH) consortium

Substance use disorders (SUD) and drug addiction are major threats to public health, impacting not only the millions of individuals struggling with SUD, but also surrounding families and communities. One of th...

Seth A. Ament, Rianne R. Campbell, Mary Kay Lobo… in Molecular Psychiatry (2024)

Article

In-vitro and in-vivo assessment of nirmatrelvir penetration into CSF, central nervous system cells, tissues, and peripheral blood mononuclear cells

Three years after SARS-CoV-2 emerged as a global infectious threat, the virus has become endemic. The neurological complications such as depression, anxiety, and other CNS complications after COVID-19 disease ...

Sean N. Avedissian, Johid R. Malik, Anthony T. Podany, Michael Neely… in Scientific Reports (2024)

Article

Transformation of dolutegravir into an ultra-long-acting parenteral prodrug formulation

Ultra-long-acting integrase strand transfer inhibitors were created by screening a library of monomeric and dimeric dolutegravir (DTG) prodrug nanoformulations. This led to an 18-carbon chain modified ester pr...

Suyash Deodhar, Brady Sillman, Aditya N. Bade, Sean N. Avedissian… in Nature Communications (2022)

Article

An emerging and variant viral promoter of HIV-1 subtype C exhibits low-level gene expression noise

We observe the emergence of several promoter-variant viral strains in India during recent years. The variant viral promoters contain additional copies of transcription factor binding sites present in the viral...

Haider Ali, Disha Bhange, Kavita Mehta, Yuvrajsinh Gohil… in Retrovirology (2021)

Article

In-vitro Immunomodulatory activity of Azadirachta indica A.Juss. Ethanol: water mixture against HIV associated chronic CD4⁺ T-cell activation/ exhaustion

In Sub-Saharan Africa, herbal therapy continues to be utilized for HIV-1 disease management. However, the therapeutic benefits of these substances remain ambiguous. To date, little is known about the effects o...

Omalla A. Olwenyi, Bannet Asingura… in BMC Complementary Medicine and Therapies (2021)

Article

Zika virus infection induces endoplasmic reticulum stress and apoptosis in placental trophoblasts

Zika virus (ZIKV) infection to a pregnant woman can be vertically transmitted to the fetus via the placenta leading to Congenital Zika syndrome. This is characterized by microcephaly, retinal defects, and intr...

Philma Glora Muthuraj, Prakash K. Sahoo, Madison Kraus… in Cell Death Discovery (2021)

Article

Infectivity of SARS-CoV-2: there Is Something More than D614G?

Saathvik R. Kannan, Austin N. Spratt… in Journal of Neuroimmune Pharmacology (2020)

Article

Immuno-epidemiology and pathophysiology of coronavirus disease 2019 (COVID-19)

Occasional zoonotic viral attacks on immunologically naive populations result in massive death tolls that are capable of threatening human survival. Currently, severe acute respiratory syndrome coronavirus 2 (...

Omalla A. Olwenyi, Shetty Ravi Dyavar, Arpan Acharya… in Journal of Molecular Medicine (2020)

Article

SARS-CoV-2 Infection Leads to Neurological Dysfunction

A number of neurological disease complications have been seen following infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). While most person with COVID-19 respiratory disease demo...

Arpan Acharya, Bhavesh D. Kevadiya… in Journal of Neuroimmune Pharmacology (2020)

Article

A Tat/Rev Induced Limiting Dilution Assay to Measure Viral Reservoirs in Non-Human Primate Models of HIV Infection

The establishment of latent infection and poorly characterized viral reservoirs in tissues represent major obstacles to a definitive cure for HIV. Non-human primate (NHP) models of HIV infection are critical t...

Ines Frank, Arpan Acharya, Nanda K. Routhu, Meropi Aravantinou… in Scientific Reports (2019)

Article

Correction to: Zika Virus and the Metabolism of Neuronal Cells

The original version of this article unfortunately contained mistake.

Hussin A. Rothan, Shengyun Fang, Mahesh Mohan… in Molecular Neurobiology (2019)

Article

The Role of Integrin α₄β₇ in HIV Pathogenesis and Treatment

Acute HIV infection is characterized by high-level viral replication throughout the body’s lymphoid system, particularly in gut-associated lymphoid tissues resulting in damage to structural components of gut t...

James Arthos, Claudia Cicala, Fatima Nawaz… in Current HIV/AIDS Reports (2018)

Article

Normalization of cell associated antiretroviral drug concentrations with a novel RPP30 droplet digital PCR assay

Quantification of antiretroviral (ARV) drug concentrations in peripheral blood mononuclear cells (PBMCs) and tissue isolated mononuclear cells (TIMCs) from lymph node (LNMC) and rectum (RMC) is an important me...

Shetty Ravi Dyavar, Zhen Ye, Siddappa N. Byrareddy… in Scientific Reports (2018)