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  1. No Access

    Article

    Repeated mRNA vaccination sequentially boosts SARS-CoV-2-specific CD8+ T cells in persons with previous COVID-19

    Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) hybrid immunity is more protective than vaccination or previous infection alone. To investigate the kinetics of spike-reactive T (TS) cells from SARS-C...

    Emily S. Ford, Koshlan Mayer-Blackwell, Lichen **g, Kerry J. Laing… in Nature Immunology (2024)

  2. Article

    Open Access

    Serological fingerprints link antiviral activity of therapeutic antibodies to affinity and concentration

    The effectiveness of therapeutic monoclonal antibodies (mAbs) against variants of the SARS-CoV-2 virus is highly variable. As target recognition of mAbs relies on tight binding affinity, we assessed the affini...

    Sebastian Fiedler, Sean R. A. Devenish, Alexey S. Morgunov… in Scientific Reports (2022)

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  3. Article

    Open Access

    Structural definition of a pan-sarbecovirus neutralizing epitope on the spike S2 subunit

    Three betacoronaviruses have crossed the species barrier and established human-to-human transmission causing significant morbidity and mortality in the past 20 years. The most current and widespread of these i...

    Nicholas K. Hurlburt, Leah J. Homad, Irika Sinha… in Communications Biology (2022)

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  4. Article

    Open Access

    Passive immunization of macaques with polyclonal anti-SHIV IgG against a heterologous tier 2 SHIV: outcome depends on IgG dose

    A key goal for HIV-1 envelope immunogen design is the induction of cross-reactive neutralizing antibodies (nAbs). As AIDS vaccine recipients will not be exposed to strains exactly matching any immunogens due t...

    Anton M Sholukh, Siddappa N Byrareddy, Vivekanandan Shanmuganathan… in Retrovirology (2014)

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