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Article
Open AccessWhole genome and RNA sequencing analyses for 254 Taiwanese hepatocellular carcinomas
Comprehensive and integrative analysis of hepatocellular carcinoma (HCC) is important. In this study, we explored Taiwanese HCCs using multi-omics analyses.
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Article
Integrated genomic analyses of hepatocellular carcinoma
Genomic alterations play important roles in the development of cancer. We explored the impact of protein-coding genes and transcriptomic changes on clinical and molecular alterations in Taiwanese hepatocellula...
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Article
Open AccessSingle-cell RNA sequencing of immune cells in patients with acute gout
Cell subpopulations in the blood and joint fluid of patients with gout are poorly understood. Single-cell RNA sequencing and bioinformatic tools were used to identify cell subsets and their gene signatures in ...
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Article
Open AccessMutation profile of non-small cell lung cancer revealed by next generation sequencing
Precision therapy for lung cancer requires comprehensive genomic analyses. Specific effects of targeted therapies have been reported in Asia populations, including Taiwanese, but genomic studies have rarely be...
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Article
Open AccessMulti-omics profiling reveals microRNA-mediated insulin signaling networks
MicroRNAs (miRNAs) play a key role in mediating the action of insulin on cell growth and the development of diabetes. However, few studies have been conducted to provide a comprehensive overview of the miRNA-m...
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Article
Open AccessEnterotype-based Analysis of Gut Microbiota along the Conventional Adenoma-Carcinoma Colorectal Cancer Pathway
The dysbiosis of human gut microbiota is strongly associated with the development of colorectal cancer (CRC). The dysbiotic features of the transition from advanced polyp to early-stage CRC are largely unknown...
