124 Result(s)

Article

Inhibition of cysteine-serine-rich nuclear protein 1 ameliorates ischemia–reperfusion injury during liver transplantation in an MAPK-dependent manner

Hepatic ischemia–reperfusion injury (HIRI) is a critical pathophysiological process during liver transplantation (LT). Multiple genes and signal pathways are dysregulated during HIRI. This study aims to identi...

Zhoucheng Wang, Wenwen Ge, **nyang Zhong, Shizheng Tong… in Molecular Biomedicine (2024)

Article

The dysregulation of biliary tract microflora is closely related to primary choledocholithiasis: a multicenter study

Bile microecology changes play an important role in the occurrence and development of choledocholithiasis. At present, there is no clear report on the difference of bile microecology between asymptomatic patie...

Min **ao, Yankun Zhou, Zhengfei Wang, Wenchao Dai, Di Wang… in Scientific Reports (2024)

Article

mTOR inhibitor reduces nontumour-related death in liver transplantation for hepatocellular carcinoma

Sirolimus is a regularly applied immunosuppressant for patients undergoing liver transplantation (LT) for hepatocellular carcinoma (HCC). Sirolimus not only significantly inhibits HCC recurrence but also prote...

Lincheng Zhang, Peng Liu, Li Zhuang, Sunbin Ling, Qifan Zhan… in Molecular Biomedicine (2024)

Article

Integrated multi-omic analysis identifies fatty acid binding protein 4 as a biomarker and therapeutic target of ischemia–reperfusion injury in steatotic liver transplantation

Due to a lack of donor grafts, steatotic livers are used more often for liver transplantation (LT). However, steatotic donor livers are more sensitive to ischemia–reperfusion (IR) injury and have a worse progn...

Mengfan Yang, Wenzhi Shu, **angyu Zhai, **nyu Yang… in Cellular and Molecular Life Sciences (2024)

Article

Gp78 deficiency in hepatocytes alleviates hepatic ischemia-reperfusion injury via suppressing ACSL4-mediated ferroptosis

Ferroptosis, which is driven by iron-dependent lipid peroxidation, plays an essential role in liver ischemia-reperfusion injury (IRI) during liver transplantation (LT). Gp78, an E3 ligase, has been implicated ...

Changbiao Li, Yichao Wu, Kangchen Chen, Ronggao Chen, Shengjun Xu… in Cell Death & Disease (2023)

Article

Liver organoid culture methods

Organoids, three-dimensional structures cultured in vitro, can recapitulate the microenvironment, complex architecture, and cellular functions of in vivo organs or tissues. In recent decades, liver organoids h...

Yiqing Hu, **aoyi Hu, Jia Luo, Jiacheng Huang, Yaohan Sun, Haoyu Li… in Cell & Bioscience (2023)

Article

Insulin-induced gene 2 protects against hepatic ischemia–reperfusion injury via metabolic remodeling

Hepatic ischemia–reperfusion (IR) injury is the primary reason for complications following hepatectomy and liver transplantation (LT). Insulin-induced gene 2 (Insig2) is one of several proteins that anchor the...

Yichao Wu, Changbiao Li, Abid Ali Khan, Kangchen Chen… in Journal of Translational Medicine (2023)

Article

Application of multi-modality MRI-based radiomics in the pre-treatment prediction of RPS6K expression in hepatocellular carcinoma

In this study, we aim to develop and validate a radiomics model for pretreatment prediction of RPS6K expression in hepatocellular carcinoma (HCC) patients, thus hel** clinical decision-making of mTOR-inhibit...

Fan Yang, Yidong Wan, **aoyong Shen, Yichao Wu, Lei Xu… in Molecular Biomedicine (2023)

Article

Development and validation of a nomogram model for predicting chronic kidney disease after liver transplantation: a multi-center retrospective study

Chronic kidney disease (CKD) is a frequent complication after liver transplantation (LT) and associated with poor prognosis. In this study, we retrospectively analyzed 515 adult patients who underwent LT in ou...

Zenglei He, Yimou Lin, Siyi Dong, Qinghong Ke, Shusen Zheng, Qi Ling in Scientific Reports (2023)

Article

The predictive value of the modified AFP model for liver transplantation outcomes in multinodular hepatocellular carcinoma patients

There is a lack of studies focusing on the benefit of liver transplantation (LT) in hepatocellular carcinoma (HCC) patients with > 3 tumors. This study aims to establish a model to effectively predict overall ...

**grui Wang, Jiaqi Bao, Rui Wang, Jiachen Hong… in World Journal of Surgical Oncology (2023)

Article

Liver Organoids, Novel and Promising Modalities for Exploring and Repairing Liver Injury

The past decades have witnessed great advances in organoid technology. Liver is the biggest solid organ, performing multifaceted physiological functions. Nowadays, liver organoids have been applied in many fie...

Chiyu He, Di Lu, Zuyuan Lin, Hao Chen, Huigang Li… in Stem Cell Reviews and Reports (2023)

Article

KLF14 regulates the growth of hepatocellular carcinoma cells via its modulation of iron homeostasis through the repression of iron-responsive element-binding protein 2

Hepatocellular carcinoma (HCC) is a multifactor-driven malignant tumor with rapid progression, which causes the difficulty to substantially improve the prognosis of HCC. Limited understanding of the mechanisms...

Hui Zhou, Junru Chen, Mingjie Fan… in Journal of Experimental & Clinical Cancer … (2023)

Article

Intratumoral bacteria interact with metabolites and genetic alterations in hepatocellular carcinoma

Chen Xue, Junjun Jia, **nyu Gu, Lin Zhou… in Signal Transduction and Targeted Therapy (2022)

Article

USP15 regulates p66Shc stability associated with Drp1 activation in liver ischemia/reperfusion

Liver ischemia/reperfusion (I/R) injury is a major clinical concern of liver transplantation, which accounts for organ rejection and liver dysfunction. The adaptor protein p66Shc acts as a crucial redox enzyme...

**nyao Tian, Yan Zhao, Zhe Yang, Qianrang Lu, Lin Zhou… in Cell Death & Disease (2022)

Article

Deep learning for prediction of hepatocellular carcinoma recurrence after resection or liver transplantation: a discovery and validation study

There is a growing need for new improved classifiers of prognosis in hepatocellular carcinoma (HCC) patients to stratify them effectively.

Zhikun Liu, Yuanpeng Liu, Wenhui Zhang, Yuan Hong, **wen Meng… in Hepatology International (2022)