53 Result(s)

Article

Substitution of calcineurin inhibitors with corticosteroids after allogeneic hematopoietic cell transplantation

Combination of calcineurin inhibitors (CIs) with short-term methotrexate is a standard prophylactic regimen for graft-versus-host disease (GVHD). However, it is sometimes difficult to continue CIs due to adver...

Shimpei Matsumi, Shun-ichi Kimura, Yuhei Nakamura… in International Journal of Hematology (2023)

Article

Plasma ubiquitin C-terminal hydrolase-L1 (UCH-L1) level as a blood biomarker of neurological damage after allogeneic hematopoietic cell transplantation

Several biofluid-based biomarkers for traumatic brain injury show promise for use in diagnosis and outcome prediction. In contrast, few studies have investigated biomarkers for non-traumatic brain injury. We f...

Yosuke Okada, Hideki Nakasone, Kazuki Yoshimura… in International Journal of Hematology (2023)

Article

Impact of standard-dose dipeptidyl peptidase-4 inhibitors on the incidence of graft-versus-host disease after allogeneic hematopoietic cell transplantation

Shun-ichi Kimura, Hiroaki Shimizu, Takuya Miyazaki… in Bone Marrow Transplantation (2023)

Article

Very early death within 30 days after diagnosis in patients with acute myeloid leukemia

Acute myeloid leukemia (AML) is a malignancy that requires immediate treatment. However, the factors that predict very early mortality are not well known. We retrospectively analyzed 70 patients who were newly...

Machiko Kusuda, Hideki Nakasone, Yuhei Nakamura… in International Journal of Hematology (2023)

Article

Pancreatic atrophy and recovery after allogeneic hematopoietic cell transplantation

Pancreatic atrophy after allogeneic hematopoietic cell transplantation (HCT) is one of the symptoms associated with chronic graft-versus-host disease (GVHD). Although pancreatic atrophy has been considered to cau...

Yosuke Okada, Hideki Nakasone, Yuhei Nakamura… in Journal of Gastroenterology (2022)

Article

Comparison of the impact of two post-remission therapy regimens on cardiac events in acute myeloid leukemia patients undergoing allogeneic hematopoietic stem cell transplantation

High-dose cytarabine (HD-AraC) or anthracycline-containing chemotherapies are used as post-remission therapy for acute myeloid leukemia (AML) patients. However, it remains unclear which regimen would be better...

** Hayakawa, Hideki Nakasone, Daisuke Minakata… in International Journal of Hematology (2022)

Article

Emergence of clone with PHF6 nonsense mutation in chronic myelomonocytic leukemia at relapse after allogeneic HCT

Disease relapse is a major cause of treatment failure after allogeneic hematopoietic cell transplantation (HCT) and the mechanisms of relapse remain unclear. We encountered a 58-year-old man with chronic myelo...

Yu Akahoshi, Hideki Nakasone, Machiko Kusuda… in International Journal of Hematology (2022)

Article

Prognostic impact of chromosomal changes at relapse after allogeneic hematopoietic cell transplantation for acute myeloid leukemia or myelodysplastic syndrome

Chromosome analysis is a powerful prognostic tool in myeloid malignancies. Recipients who experience relapse after allogeneic hematopoietic cell transplantation (allo-HCT) often show chromosomal changes betwee...

Yosuke Okada, Hideki Nakasone, Yuhei Nakamura… in Bone Marrow Transplantation (2022)

Article

Chronic liver graft-versus-host disease in allogeneic hematopoietic stem cell transplantation recipients during tapering or after stop** calcineurin inhibitors

Chronic graft-versus-host disease (cGVHD) of the liver is often observed in allogeneic hematopoietic stem cell transplantation (allo-HSCT) during tapering or after stop** calcineurin inhibitors (CI). We cond...

Kazuki Yoshimura, Shun-ichi Kimura… in International Journal of Hematology (2021)

Article

Cytomegalovirus reactivation is associated with an increased risk of late-onset invasive aspergillosis independently of grade II–IV acute graft-versus-host disease in allogeneic hematopoietic stem cell transplantation: JSTCT Transplant Complications Working Group

There is a matter of debate about the clinical impact of cytomegalovirus (CMV) reactivation on the development of late-onset invasive aspergillosis (IA), which occurs 40 days or later after allogeneic hematopo...

Shun-ichi Kimura, Masaharu Tamaki, Keiji Okinaka, Sachiko Seo… in Annals of Hematology (2021)

Article

Pre-conditioning intervention in patients with relapsed or refractory acute lymphoblastic leukemia who underwent allogeneic hematopoietic cell transplantation: a KSGCT multicenter retrospective analysis

The efficacy and clinical significance of pre-conditioning intervention (PCI) before allogeneic hematopoietic cell transplantation (HCT) in patients with acute lymphoblastic leukemia (ALL) not in remission rem...

Takayoshi Tachibana, Junya Kanda, Takuma Ishizaki, Yuho Najima… in Annals of Hematology (2021)

Article

Predictive and risk factor analysis for bloodstream infection in high-risk hematological patients with febrile neutropenia: post-hoc analysis from a prospective, large-scale clinical study

Bloodstream infection (BSI) is a frequent complication observed in patients with febrile neutropenia (FN). BSI risk factors and incidence vary depending on chemotherapy types and prophylactic antimicrobial age...

Akinao Okamoto, Yoshinobu Kanda, Shun-ichi Kimura… in International Journal of Hematology (2021)

Article

Prognostic factors in salvage transplantation for graft failure following allogeneic hematopoietic stem cell transplantation

Although graft failure (GF) is a fatal complication after allogeneic stem cell transplantation (SCT), no mortality risk assessments after salvage SCT have been reported. We developed a comprehensive prognostic...

Kaito Harada, Shun-ichi Kimura, Shigeo Fuji, Yuho Najima… in Bone Marrow Transplantation (2021)

Article

Real-world management of infection during chemotherapy for acute leukemia in Japan: from the results of a nationwide questionnaire-based survey by the Japan Adult Leukemia Study Group

We conducted a nationwide questionnaire-based survey in 2019 following 2001, 2007 and 2013 surveys to clarify the real-world management of infection during chemotherapy for acute leukemia in Japan. An online q...

Shun-ichi Kimura, Hiroyuki Fujita, Hiroshi Handa… in International Journal of Hematology (2020)

Article

Allogeneic hematopoietic cell transplantation in patients with untreated acute myeloid leukemia: a KSGCT multicenter retrospective analysis

Takayoshi Tachibana, Takuma Ishizaki, Satoshi Takahashi… in Bone Marrow Transplantation (2020)

Article

Impact of blood pressure early after allogeneic hematopoietic cell transplantation on clinical outcomes

Allogeneic hematopoietic transplantation (allo-HCT) is still associated with significant morbidity and mortality, and risk stratification is critical. In this study, we analyzed the relationship between blood ...

Masaharu Tamaki, Hideki Nakasone, Shunto Kawamura, Junko Takeshita… in Annals of Hematology (2020)