49 Result(s)

Article

The basal forebrain to lateral habenula circuitry mediates social behavioral maladaptation

Elucidating the neural basis of fear allows for more effective treatments for maladaptive fear often observed in psychiatric disorders. Although the basal forebrain (BF) has an essential role in fear learning,...

Jun Wang, Qian Yang, Xue Liu, Jie Li, Ya-Lan Wen, Yuzheng Hu… in Nature Communications (2024)

Article

Morphological Tracing and Functional Identification of Monosynaptic Connections in the Brain: A Comprehensive Guide

Behavioral studies play a crucial role in unraveling the mechanisms underlying brain function. Recent advances in optogenetics, neuronal ty** and labeling, and circuit tracing have facilitated the dissection...

Yuanyuan Li, Yuanyuan Fang, Kaiyuan Li, Hongbin Yang, Shumin Duan… in Neuroscience Bulletin (2024)

Article

Temporal-spatial Generation of Astrocytes in the Develo** Diencephalon

Astrocytes are the largest glial population in the mammalian brain. However, we have a minimal understanding of astrocyte development, especially fate specification in different regions of the brain. Through l...

Wentong Hong, Pifang Gong, **njie Pan, Zhonggan Ren, Yitong Liu… in Neuroscience Bulletin (2024)

Article

Author Correction: Sustained antidepressant effect of ketamine through NMDAR trap** in the LHb

Shuangshuang Ma, Min Chen, Yihao Jiang, **nkuan **ang, Shiqi Wang, Zuohang Wu… in Nature (2023)

Article

Sustained antidepressant effect of ketamine through NMDAR trap** in the LHb

Ketamine, an N-methyl-d-aspartate receptor (NMDAR) antagonist¹, has revolutionized the treatment of depression because of its potent, rapid and sustained antidepressant effects^2–4. Although the elimination half-l...

Shuangshuang Ma, Min Chen, Yihao Jiang, **nkuan **ang, Shiqi Wang, Zuohang Wu… in Nature (2023)

Article

Oral intake of titanium dioxide nanoparticles affect the course and prognosis of ulcerative colitis in mice: involvement of the ROS-TXNIP-NLRP3 inflammasome pathway

Titanium dioxide (TiO₂), no matter in nanoscale or micron sizes, has been widely used in food industry as additives for decades. Given the potential impact of TiO₂ on the gastrointestinal epithelial and parenchym...

Shumin Duan, Hongbo Wang, Yanjun Gao, **ang Wang… in Particle and Fibre Toxicology (2023)

Article

Novel Insight into Glial Biology and Diseases

Cheng He, Shumin Duan in Neuroscience Bulletin (2023)

Article

Robust and adjustable dynamic scattering compensation for high-precision deep tissue optogenetics

The development of high-precision optogenetics in deep tissue is limited due to the strong optical scattering induced by biological tissue. Although various wavefront sha** techniques have been developed to ...

Zhenghan Li, Yameng Zheng, **ntong Diao, Rongrong Li, Ning Sun… in Communications Biology (2023)

Article

Dual roles of hexokinase 2 in sha** microglial function by gating glycolytic flux and mitochondrial activity

Microglia continuously survey the brain parenchyma and actively shift status following stimulation. These processes demand a unique bioenergetic programme; however, little is known about the metabolic determin...

Yaling Hu, Kelei Cao, Fang Wang, Weiying Wu, Weihao Mai, Liyao Qiu… in Nature Metabolism (2022)

Article

Activated astrocytes attenuate neocortical seizures in rodent models through driving Na⁺-K⁺-ATPase

Epileptic seizures are widely regarded to occur as a result of the excitation-inhibition imbalance from a neuro-centric view. Although astrocyte-neuron interactions are increasingly recognized in seizure, elem...

Junli Zhao, **yi Sun, Yang Zheng, Yanrong Zheng, Yuying Shao… in Nature Communications (2022)

Article

A short period of early life oxytocin treatment rescues social behavior dysfunction via suppression of hippocampal hyperactivity in male mice

Early sensory experiences interact with genes to shape precise neural circuits during development. This process is vital for proper brain function in adulthood. Neurological dysfunctions caused by environmenta...

Libiao Pan, Lu Zheng, **aotong Wu, Zhenggang Zhu, Siyu Wang, Yi Lu… in Molecular Psychiatry (2022)

Article

Organizational principles of amygdalar input-output neuronal circuits

The amygdala, one of the most studied brain structures, integrates brain-wide heterogeneous inputs and governs multidimensional outputs to control diverse behaviors central to survival, yet how amygdalar input...

Limeng Huang, Yiwen Chen, Sen **, Li Lin, Shumin Duan, Ke Si… in Molecular Psychiatry (2021)

Article

NG2 glia-derived GABA release tunes inhibitory synapses and contributes to stress-induced anxiety

NG2 glia, also known as oligodendrocyte precursor cells (OPCs), play an important role in proliferation and give rise to myelinating oligodendrocytes during early brain development. In contrast to other glial ...

**ao Zhang, Yao Liu, **aoqi Hong, **a Li, Charles K. Meshul… in Nature Communications (2021)

Article

The noncanonical role of the protease cathepsin D as a cofilin phosphatase

Cathepsin D (cathD) is traditionally regarded as a lysosomal protease that degrades substrates in acidic compartments. Here we report cathD plays an unconventional role as a cofilin phosphatase orchestrating a...

Yi-Jun Liu, Ting Zhang, Sicong Chen, Daxiao Cheng, Cun** Wu, **ngyue Wang… in Cell Research (2021)

Article

Histamine H₁ receptor deletion in cholinergic neurons induces sensorimotor gating ability deficit and social impairments in mice

Negative symptoms in schizophrenia strongly contribute to poor functional outcomes, however its pathogenesis is still unclear. Here, we found that histamine H₁ receptor (H₁R) expression in basal forebrain (BF) ch...

Li Cheng, Cenglin Xu, Lu Wang, Dadao An, Lei Jiang, Yanrong Zheng… in Nature Communications (2021)

Article

The combined effect of food additive titanium dioxide and lipopolysaccharide on mouse intestinal barrier function after chronic exposure of titanium dioxide-contained feedstuffs

Up to 44% of particulates of food-grade titanium dioxide (TiO₂) are in nanoscale, while the effect and combined effect of which with other substances on intestinal barrier haven’t been fully understood yet. This ...

Yongliang Zhang, Shumin Duan, Ying Liu, Yun Wang in Particle and Fibre Toxicology (2021)

Article

Parabrachial nucleus circuit governs neuropathic pain-like behavior

The lateral parabrachial nucleus (LPBN) is known to relay noxious information to the amygdala for processing affective responses. However, it is unclear whether the LPBN actively processes neuropathic pain cha...

Li Sun, Rui Liu, Fang Guo, Man-qing Wen, **ao-lin Ma, Kai-yuan Li… in Nature Communications (2020)