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  1. No Access

    Article

    Novel STAT3 oligonucleotide compounds suppress tumor growth and overcome the acquired resistance to sorafenib in hepatocellular carcinoma

    Signal transducer and activator of transcription 3 (STAT3) plays an important role in the occurrence and progression of tumors, leading to resistance and poor prognosis. Activation of STAT3 signaling is freque...

    Qi-yi Zhang, Wen Ding, Jian-shan Mo, Shu-min Ou-yang… in Acta Pharmacologica Sinica (2024)

  2. No Access

    Article

    The novel STAT3 inhibitor WZ-2-033 causes regression of human triple-negative breast cancer and gastric cancer xenografts

    Hyperactive signal transducer and activator of transcription 3 (STAT3) signaling is frequently detected in human triple-negative breast cancer (TNBC) and gastric cancer, leading to uncontrolled tumor growth, r...

    Yan Zhong, Lin Deng, Shuo Shi, Qiu-yao Huang, Shu-min Ou-Yang… in Acta Pharmacologica Sinica (2022)