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13 Result(s)

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  1. Article

    Open Access

    Targeting FROUNT with disulfiram suppresses macrophage accumulation and its tumor-promoting properties

    Tumor-associated macrophages affect tumor progression and resistance to immune checkpoint therapy. Here, we identify the chemokine signal regulator FROUNT as a target to control tumor-associated macrophages. T...

    Yuya Terashima, Etsuko Toda, Meiji Itakura, Mikiya Otsuji… in Nature Communications (2020)

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  2. Article

    Open Access

    CXCL4/Platelet Factor 4 is an agonist of CCR1 and drives human monocyte migration

    Activated platelets release micromolar concentrations of the chemokine CXCL4/Platelet Factor-4. Deposition of CXCL4 onto the vascular endothelium is involved in atherosclerosis, facilitating monocyte arrest an...

    James M. Fox, Fahima Kausar, Amy Day, Michael Osborne, Khansa Hussain… in Scientific Reports (2018)

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  3. No Access

    Article

    Pivotal function for cytoplasmic protein FROUNT in CCR2-mediated monocyte chemotaxis

    Ligation of the chemokine receptor CCR2 on monocytes and macrophages with its ligand CCL2 results in activation of the cascade consisting of phosphatidylinositol-3-OH kinase (PI(3)K), the small G protein Rac a...

    Yuya Terashima, Nobuyuki Onai, Masako Murai, Masahiko Enomoto… in Nature Immunology (2005)

  4. No Access

    Article

    Neutrophil Cytoskeletal Disease

    Neutrophils and other phagocytes migrate to the site of infection, ingest pathogens, and destroy them after releasing granule contents and active oxygen. These activities of the cells are closely associated wi...

    Hiroyuki Nunoi, Tsuyoshi Yamazaki, Shiro Kanegasaki in International Journal of Hematology (2001)

  5. No Access

    Article

    Statistical and mutational analysis of chronic granulomatous disease in Japan with special reference to gp91-phox and p22-phox deficiency

    Chronic granulomatous disease (CGD) is a group of inherited disorders of host defense caused by a mutation in any of the four components of phagocyte NADPH oxidase, namely gp91-, p22-, p47-, and p67-phox. We hav...

    Fuminari Ishibashi, Hiroyuki Nunoi, Fumio Endo, Ichiro Matsuda… in Human Genetics (2000)

  6. No Access

    Article

    Drug-selected complete restoration of superoxide generation in Epstein-Barr virus-transformed B cells from p47 phox -deficient chronic granulomatous disease patients by using a bicistronic retrovirus vector encoding a human multi-drug resistance gene (MDR1) and the p47 phox gene

    Chronic granulomatous disease (CGD) is a group of disorders characterized by the failure of phagocytes to produce superoxide. One-third of the cases of CGD in the USA and Europe results from defects in the gen...

    Mayumi Iwata, Hiroyuki Nunoi, Ichiro Matsuda, Shiro Kanegasaki… in Human Genetics (1998)

  7. No Access

    Article

    A 25-kb deletion in the 5′ region of the cytochrome b558 heavy chain gene (CYBB) in a patient with X-linked chronic granulomatous disease

    We performed molecular genetic analyses of the family of a boy suffering from chronic granulomatous disease (CGD) after immunocytochemically confirming him and his mother to be an X-linked CGD patient and a m...

    N. N. Faizunnessa, T. Tsuchiya, Atsushi Kumatori, H. Kurozumi… in Human Genetics (1997)

  8. No Access

    Article

    Antimetastatic activity of lipopolysaccharide against a NK-resistant murine fibrosarcoma

    An intravenous injection of bacterial lipopolysaccharide (LPS) into mice exerted prominent antimetastatic activities against a NK-resistant weakly immunogenic NFSa fibrosarcoma. The number of visible metastase...

    Tatsuo Jibul, Sachiko Koike, Koichi Ando… in Clinical & Experimental Metastasis (1993)

  9. No Access

    Article

    Significance of platelets in an antimetastatic activity of bacterial lipopolysaccharide

    Recently we reported an antimetastatic activity of bacterial lipopolysaccharide (LPS) on a NK-cell-resistant murine fibrosarcoma (NFSa). Here we investigate and report the mechanistic significance of platelets...

    Dr Masashi Kimoto, Koichi Ando, Sachiko Koike… in Clinical & Experimental Metastasis (1993)

  10. Article

    Genetic Heterogeneity in Patients with X-Linked Recessive Chronic Granulomatous Disease

    ABSTRACT: Genetic heterogeneity in 12 patients from 11 different families with X-linked recessive chronic granu-kHnatoas disease was studied by Southern blot analysis using cytochrome b heavy-chain cDNA as a prob...

    Tadashi Ariga, Masanori Nakanishi, Kazuhiro Tomizawa… in Pediatric Research (1992)

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  11. No Access

    Article

    Active components of intestinal bacteria for abdominal irradiation-induced inhibition of lung metastases

    We have previously reported that abdominal irradiation of mice inhibited lung metastases of a weakly immunogenic fibrosarcoma, and that transmigration after the irradiation ofEnterobacter cloacae into mesenteric ...

    Tatsuo Jibu, Koichi Ando, Tsuneya Matsumoto… in Clinical & Experimental Metastasis (1991)

  12. No Access

    Chapter and Conference Paper

    Responses of Phagocytosis to Bacteria

    One of the earliest responses of host upon bacterial infection may be mobilization of phagocytes such as neutrophils and macrophages to the site of infection. These phagocytes are armed well in various ways an...

    Shiro Kanegasaki in Bacteria, Complement and the Phagocytic Cell (1988)

  13. No Access

    Chapter

    Lipopolysaccharide as a Bacteriophage Receptor

    Lipopolysaccharides of gram-negative bacteria have been the subject of numerous reviews which deal with their structure (Lüderitz et al., 1971; Wilkinson, 1977), biosynthesis (Nikaido, 1973; Wright and Kanegasaki...

    Andrew Wright, Michael McConnell, Shiro Kanegasaki in Virus Receptors (1980)