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Article
Open AccessLocal excision versus radical surgery for anal squamous cell carcinoma: a multicenter study in Japan
The standard treatment for anal squamous cell carcinoma is chemoradiation therapy (CRT), but there is a possibility of over-treatment for early-stage disease. cTisN0 and cT1N0 disease is currently indicated fo...
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Article
Determination of the positional relationship of the second Houston valve and peritoneal reflection using computed tomographic colonography and magnetic resonance imaging
The second Houston valve is used as a surrogate for estimating the position of the peritoneal reflection; however, the concordance between the positions of the valve and peritoneal reflection has not been inve...
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Article
Open AccessThe transcription factor ATF3 switches cell death from apoptosis to necroptosis in hepatic steatosis in male mice
Hepatocellular death increases with hepatic steatosis aggravation, although its regulation remains unclear. Here we show that hepatic steatosis aggravation shifts the hepatocellular death mode from apoptosis t...
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Article
Open AccessGeneration of transgenic mice expressing a FRET biosensor, SMART, that responds to necroptosis
Necroptosis is a regulated form of cell death involved in various pathological conditions, including ischemic reperfusion injuries, virus infections, and drug-induced tissue injuries. However, it is not fully ...
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Article
Computed tomographic colonography versus double-contrast barium enema for the preoperative evaluation of rectal cancer
We investigated whether or not computed tomographic colonography (CTC) is a viable alternative to double-contrast barium enema (BE) for a preoperative rectal cancer evaluation.
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Article
Open AccessMIND bomb 2 prevents RIPK1 kinase activity-dependent and -independent apoptosis through ubiquitylation of cFLIPL
Mind bomb 2 (MIB2) is an E3 ligase involved in Notch signalling and attenuates TNF-induced apoptosis through ubiquitylation of receptor-interacting protein kinase 1 (RIPK1) and cylindromatosis. Here we show th...
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Protocol
Time-Lapse Imaging of Necroptosis and DAMP Release at Single-Cell Resolution
Necroptosis is a regulated form of necrosis that depends on receptor-interacting protein kinase (RIPK)3 and mixed lineage kinase domain-like protein (MLKL). Necroptotic cells release a variety of cellular and ...
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Article
Open AccessAddendum: A FRET biosensor for necroptosis uncovers two different modes of the release of DAMPs
The cDNA sequence of human SMART described in this Article was misreported, as described in the accompanying Addendum. This error does not affect the results or any conclusion of the Article.
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Article
Laparoscopic treatment of a vesicointestinal fistula due to a Meckel’s diverticulum: a case report and review of the literature
While there have been numerous reports about colovesical fistulas and ruptured intestinal diverticula, there have been far fewer reports about vesicointestinal fistulas caused by Meckel’s diverticula. Most Mec...
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Article
Open AccessA FRET biosensor for necroptosis uncovers two different modes of the release of DAMPs
Necroptosis is a regulated form of necrosis that depends on receptor-interacting protein kinase (RIPK)3 and mixed lineage kinase domain-like (MLKL). While danger-associated molecular pattern (DAMP)s are involv...
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Article
Open AccessNovel method to rescue a lethal phenotype through integration of target gene onto the X-chromosome
The loss-of-function mutations of serine protease inhibitor, Kazal type 1 (SPINK1) gene are associated with human chronic pancreatitis, but the underlying mechanisms remain unknown. We previously reported that mi...
