14 Result(s)

Article

Immunotherapy in high-risk chemotherapy-resistant patients with metastatic solid tumors and hematological malignancies using intentionally mismatched donor lymphocytes activated with rIL-2: a phase I study

The feasibility and safety of immunotherapy mediated by intentionally mismatched rIL-2 activated killer lymphocytes (IMAK) with no prior stem cell engraftment was investigated in patients with advanced chemoth...

Shimon Slavin, Aliza Ackerstein, Reuven Or… in Cancer Immunology, Immunotherapy (2010)

Article

Interleukin 2 regulation following semi-allogeneic bone marrow transplantation in mice

Success of allogeneic and autologous bone marrow transplantation (BMT) is hampered by susceptibility to infection during the first two post-treatment years. Further, in treating malignant diseases, impaired an...

Ali Abdul-Hai, Arie Ben-Yehuda, Haya Galsky… in Cancer Immunology, Immunotherapy (2006)

Article

Mycophenolate mofetil does not suppress the graft-versus-leukemia effect or the activity of lymphokine-activated killer (LAK) cells in a murine model

Background: Graft-versus-leukemia (GVL) effect is an essential component in the course of allogeneic stem cell transplantation (SCT). However, both prevention and treatment of established graft-versus-host dis...

Michael Y. Shapira, Ester Hirshfeld, Lola Weiss… in Cancer Immunology, Immunotherapy (2005)

Article

Immunotherapy of murine leukemia following non-myeloablative conditioning with naïve or G-CSF mobilized blood or bone marrow stem cells

Allogeneic stem cell transplantation (SCT) is the treatment of choice for a large number of hematologic malignancies. Its major advantage over conventional chemotherapy lies in the graft-versus-leukemia (GVL) ...

Lola Weiss, Reuven Or, Shimon Slavin, Ella Naparstek… in Cancer Immunology, Immunotherapy (2004)

Article

Linomide administration following bone marrow transplantation in mice

The effect of linomide, an immunomodulatory drug, on natural killer (NK) cells and T cell-dependent immune responses following syngeneic or allogeneic bone marrow transplantation (BMT) was investigated in BALB...

Lola Weiss, Ali Abdul-Hai, Yoel Shufaro… in Cancer Immunology, Immunotherapy (2002)

Article

Nonmyeloablative stem cell transplantation for the treatment of cancer and life-threatening nonmalignant disorders: past accomplishments and future goals

Allogeneic bone marrow transplantation (BMT) or blood stem cell transplantation represents an important therapeutic tool for the treatment of otherwise incurable malignant and nonmalignant diseases. Until rec...

Shimon Slavin, Reuven Or, Memet Aker… in Cancer Chemotherapy and Pharmacology (2001)

Article

Induction of antitumor immunity by indomethacin

Irradiated tumor cells given, together with indomethacin, to syngeneic mice induced an antitumor response and conferred protection against a challenge of a lethal dose of murine mammary (4T1) and lung (3LL) c...

Shoshana Morecki, Elena Yacovlev, Yael Gelfand… in Cancer Immunology, Immunotherapy (2000)

Chapter and Conference Paper

Post-irradiated canine serum (PICS-J) stimulates megakaryocyte (MK) progenitors and thrombopoiesis in-vitro

Protracted thrombocytopenia and bleeding is a serious complication in bone marrow transplantation (BMT). While engraftment of the erythroid and myeloid progenitors occurs promptly (within two to three weeks), ...

Varda R. Deutsch, Amiram Eldor, Tom Olson, Shimon Slavin, Arnon Nagler in Gene Technology (1996)

Article

Induction of tumor immunity by intact irradiated leukemic B cells (BCL1) bearing a tumor-associated cell-surface idiotype and the costimulatory B7 molecule

The idioptypic (Id) determinant of immunoglobulin expressed on the cell surface of malignant B cells represents a prototypical tumor-associated antigen (TAA), which has been used in a purified soluble form for...

Shoshana Morecki, Sarit Levi, Yael Puyesky… in Cancer Immunology, Immunotherapy (1995)

Article

Immunological evaluation of patients with hematological malignancies receiving ambulatory cytokine-mediated immunotherapy with recombinant human interferon-α2a and interleukin-2

Immunological parameters were evaluated in patients treated with cytokine-mediated immunotherapy (CMI) consisting of low doses of recombinant human interferon α2a (rIFNα) and recombinant human interleukin-2 (r...

Shoshana Morecki, Shoshana Revel-Vilk, Corinne Nabet… in Cancer Immunology, Immunotherapy (1992)

Article

Characterization of effector cells of graft vs leukemia following allogeneic bone marrow transplantation in mice inoculated with murine B-cell leukemia

It is now widely accepted that immunocompetent lymphocytes in allogeneic bone marrow grafts exert an antileukemic effect that contributes to the cure of leukemia. Graft vs leukemia (GVL) effects independent of...

Lola Weiss, Marilyn Weigensberg, Shoshana Morecki… in Cancer Immunology, Immunotherapy (1990)

Article

Eradication of murine leukemia with histoincompatible marrow grafts in mice conditioned with total lymphoid irradiation (TLI)

Shimon Slavin, Lola Weiss, Shoshana Morecki… in Cancer Immunology, Immunotherapy (1981)