-
Article
Open AccessExportin 4 depletion leads to nuclear accumulation of a subset of circular RNAs
Numerous RNAs are exported from the nucleus, abnormalities of which lead to cellular complications and diseases. How thousands of circular RNAs (circRNAs) are exported from the nucleus remains elusive. Here, w...
-
Article
Overexpression of d-amino acid oxidase prevents retinal neurovascular pathologies in diabetic rats
Diabetic retinopathy is characterised by retinal neurodegeneration and retinal vascular abnormalities, affecting one third of diabetic patients with disease duration of more than 10 years. Accumulated evidence...
-
Article
Brain Dicer1 Is Down-Regulated in a Mouse Model of Alzheimer’s Disease Via Aβ42-Induced Repression of Nuclear Factor Erythroid 2-Related Factor 2
Dicer1 is a microRNA-processing enzyme which plays critical roles in neuronal survival and neuritogenesis. Dicer1 deletion induces neurodegeneration or degeneration in retinal pigment epithelium, which is asso...
-
Article
Open AccessRoles of NFκB-miR-29s-MMP-2 circuitry in experimental choroidal neovascularization
Previous reports have indicated that matrix metallopeptidase-2 (MMP-2) regulates angiogenic processes, which are involved in choroidal neovascularization (CNV). However, the regulation of MMP-2 in CNV has not ...
-
Article
Open AccessOverexpression of serine racemase in retina and overproduction of D-serine in eyes of streptozotocin-induced diabetic retinopathy
Recent data indicate that inflammatory mechanisms contribute to diabetic retinopathy (DR). We have determined that serine racemase (SR) expression is increased by inflammatory stimuli including liposaccharide ...
