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Article
Open AccessSMAD4 depletion contributes to endocrine resistance by integrating ER and ERBB signaling in HR + HER2− breast cancer
Endocrine resistance poses a significant clinical challenge for patients with hormone receptor-positive and human epithelial growth factor receptor 2-negative (HR + HER2−) breast cancer. Dysregulation of estro...
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Article
Open AccessAssociation of depressive symptoms and sleep disturbances with survival among US adult cancer survivors
Depression and sleep disturbances are associated with increased risks of various diseases and mortality, but their impacts on mortality in cancer survivors remain unclear. The objective of this study was to ch...
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Article
Open AccessIdentification of an HLA-A*11:01-restricted neoepitope of mutant PIK3CA and its specific T cell receptors for cancer immunotherapy targeting hotspot driver mutations
Hotspot driver mutations presented by human leukocyte antigens might be recognized by anti-tumor T cells. Based on their advantages of tumor-specificity and immunogenicity, neoantigens derived from hotspot mut...
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Article
Open AccessPrognosis and influencing factors of ER-positive, HER2-low breast cancer patients with residual disease after neoadjuvant chemotherapy: a retrospective study
Previously, we found that patients with estrogen receptor (ER)-positive, HER2-low breast cancer are resistant to neoadjuvant chemotherapy (NACT) and have worse outcomes than those who achieve pathological comp...
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Article
Microstructure Evolution and Properties of Nitrogen-Bearing Hypereutectic High Chromium Cast Iron after Quenching
High chromium cast iron (HCCI) is widely used in mining and metallurgy due to its high wear resistance. The purpose of this study is to reveal the effects of different quenching temperatures on the microstruct...
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Article
Open AccessPara-selective nitrobenzene amination lead by C(sp2)-H/N-H oxidative cross-coupling through aminyl radical
Arylamines, serving as crucial building blocks in natural products and finding applications in multifunctional materials, are synthesized on a large scale via an electrophilic nitration/reduction sequence. How...
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Article
Automatic statistical chart analysis based on deep learning method
In order to make full use of the decision support knowledge contained in the structured chart data that matches the needs of the enterprise, we propose a deep learning approach for automatic statistical chart ...
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Article
Open AccessAuthor Correction: Hydrogenated borophene enabled synthesis of multielement intermetallic catalysts
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Article
A correlated ferromagnetic polar metal by design
Polar metals have recently garnered increasing interest because of their promising functionalities. Here we report the experimental realization of an intrinsic coexisting ferromagnetism, polar distortion and m...
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Article
Open AccessUTRN as a potential biomarker in breast cancer: a comprehensive bioinformatics and in vitro study
Utrophin (UTRN), known as a tumor suppressor, potentially regulates tumor development and the immune microenvironment. However, its impact on breast cancer’s development and treatment remains unstudied. We con...
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Article
Occupational exposure to silica and risk of gastrointestinal cancers: a systematic review and meta-analysis of cohort studies
Although silica is a proven lung carcinogen, there is no convincing evidence linking crystalline silica to gastrointestinal malignancies.
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Article
Why lowland riparian trees are difficult to use for streamflow reconstruction
Existing streamflow reconstructions based on tree-ring analysis mostly rely on species from upland, mainly montane areas, while lowland species (generally plain) areas are rarely used. This limits the understa...
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Article
Study on the Plugging Mechanism of Carbon Dioxide Oil Drive in Shale
The CO2 enhanced oil recovery(EOR) technology is widely utilized in the development of shale oil reservoirs. However, reservoir plugging issues often occur during the CO2 injection process, leading to reduced ons...
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Article
“Non-criteria” antiphospholipid syndrome and autoimmune hemolytic anemia: a case report
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Article
Risk assessment and source identification of soil heavy metals: a case study of farmland soil along a river in the southeast of a mining area in Southwest China
To investigate the heavy metals (HMs) contamination of surface farmland soil along the river in the southeast of a mining area in southwest China and identify the contamination sources, 54 topsoil samples were...
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Chapter and Conference Paper
A Method for Tensile Strength Prediction of Composite Laminates
From the perspective of engineering application, a method to predict the tensile strength of the carbon fiber reinforced polymer (CFRP) was proposed using classical laminate theory and the theory of function o...
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Chapter and Conference Paper
Unpaired Image Dehazing for Real Hazy Images
Recently, image dehazing has achieved good performance benefiting from deep learning, but most of them are aimed at synthetic hazy images that have corresponding haze-free images. However, in some practical ap...
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Chapter and Conference Paper
Simulation and Test of Spatial Interference of 1000 kV Arrester
Due to the influence of phase-to-phase coupling and space coupling, it is difficult to accurately extract the resistive current in the leakage current of the 1000 kV arrester, which affects the judgment of its...
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Chapter and Conference Paper
Probability-Based Nuclei Detection and Critical-Region Guided Instance Segmentation
Nuclear instance segmentation in histopathological images is a key procedure in pathological diagnosis. In this regard, a typical class of solutions are deep learning-like nuclear instance segmentation methods...
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Article
Open AccessEmergent zero-field anomalous Hall effect in a reconstructed rutile antiferromagnetic metal
The anomalous Hall effect (AHE) that emerges in antiferromagnetic metals shows intriguing physics and offers numerous potential applications. Magnets with a rutile crystal structure have recently received atte...
