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Article
Open AccessA single-cell analysis reveals tumor heterogeneity and immune environment of acral melanoma
Acral melanoma is a dismal subtype of melanoma occurring in glabrous acral skin, and has a higher incidence in East Asians. We perform single-cell RNA sequencing for 63,394 cells obtained from 5 acral and 3 cu...
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Article
Phenotypic and genetic dissection of cadmium accumulation in roots, nodes and grains of rice hybrids
Rice accumulates higher levels of cadmium (Cd) in grain than other cereals, and hybrid rice varieties cover around half of the total rice area in China. Therefore, understanding the phenotypic and genetic char...
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Article
Open AccessThe indica nitrate reductase gene OsNR2 allele enhances rice yield potential and nitrogen use efficiency
The indica and japonica rice (Oryza sativa) subspecies differ in nitrate (NO3−) assimilation capacity and nitrogen (N) use efficiency (NUE). Here, we show that a major component of this difference is conferred by...
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Article
Open AccessOutcomes of surgery and/or combination chemotherapy for extraskeletal osteosarcoma: a single-center retrospective study from China
Extraskeletal osteosarcoma (ESOS) is an extremely rare malignancy with poor prognosis, accounting for 2–4% of all osteogenic sarcomas. The purpose of this study was to examine the oncological outcomes of this ...
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Article
Open AccessPhase II trial of VEGFR2 inhibitor apatinib for metastatic sarcoma: focus on efficacy and safety
Apatinib (YN968D1) is a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor receptor 2 (VEGFR-2). We conducted a single-arm, nonrandomized phase II study (NCT03121846) to assess the ef...
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Article
Open AccessThe Rice TCM5 Gene Encoding a Novel Deg Protease Protein is Essential for Chloroplast Development under High Temperatures
High temperature affects a broad spectrum of cellular components and metabolism in plants. The Deg/HtrA family of ATP-independent serine endopeptidases is present in nearly all organisms. Deg proteases are req...
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Article
Open AccessThe rice ALS3 encoding a novel pentatricopeptide repeat protein is required for chloroplast development and seedling growth
Pentatricopeptide repeat (PPR) proteins play essential roles in modulating the expression of organelle genes and have expanded greatly in higher plants. However, molecular mechanisms of most rice PPR genes rem...
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Article
The rice OsDG2 encoding a glycine-rich protein is involved in the regulation of chloroplast development during early seedling stage
OsDG2 gene encoded a novel chloroplast-targeted GRP in rice. Disruption of the OsDG2 would lead to delayed greening phenotype and affected expression levels of genes associated with chloroplast...
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Article
Open AccessA WUSCHEL-like homeobox gene, OsWOX3B responses to NUDA/GL-1 locus in rice
Most of the rice varieties are pubescent. However, the presence of trichomes is an undesirable characteristic in rice production because trichomes can cause atmospheric pollution. The use of glabrous rice vari...
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Article
Sugar effects on early seedling development in Arabidopsis
Sugars affect a broad variety of processes, from growth and development to gene expression. Although it has already been shown that sugars act as signaling molecules, little is known about the mechanisms by wh...
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Article
QTLs and candidate genes for chlorate resistance in rice (Oryzasativa L.)
Chlorate resistance is one of the reliable characters in Indica/Japonica classification. To understand the genetic basis of chlorate resistance is very important for revealing the evolutionary mechanism of Ind...
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Article
QTL analysis of leaf photosynthetic rate and related physiological traits in rice (Oryza sativa L.)
Photosynthesis is the primary source ofdry matter production and grain yield inrice. Study on genetics of photosynthesisand related physiological characters isvery important to rice physiologicalbreeding. In t...
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Article
Control of tillering in rice
Tillering in rice (Oryza sativa L.) is an important agronomic trait for grain production, and also a model system for the study of branching in monocotyledonous plants. Rice tiller is a specialized grain-bearing ...
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Article
Genetic analysis of rice allelopathy
A double haploid population derived from anther culture of ZYQ8/JX17, a typical indica and japonica hybrid, was used in this study. The inhibited effect of water-soluble extract of 123 DH pure lines leaves on ...
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Article
QTL analysis of rice low temperature germinability
A double haploid population, derived from anther culture of F1 hybrid between a typicalindica and ajaponica (ZYQ8/JX17), has been used to investigate the low temperature germinability (LTG) at 15°C. The low tempe...
