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Article
Open AccessThe fusion gene LRP1–SNRNP25 drives invasion and migration by activating the pJNK/37LRP/MMP2 signaling pathway in osteosarcoma
Through transcriptome sequencing, we previously identified a new osteosarcoma-specific, frequent fusion gene, LRP1–SNRNP25, and found that it played an important role in tumor cell invasion and migration. However...
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Article
Influence of Social Distance on Foreign Language Effect in Moral Judgment
Previous research has shown that moral choice depends on language, a phenomenon known as the moral foreign language effect (mFLE). The current study examines the influence of social distance on the mFLE. In Ex...
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Article
Open AccessA single-cell analysis reveals tumor heterogeneity and immune environment of acral melanoma
Acral melanoma is a dismal subtype of melanoma occurring in glabrous acral skin, and has a higher incidence in East Asians. We perform single-cell RNA sequencing for 63,394 cells obtained from 5 acral and 3 cu...
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Article
Open AccessOutcomes of surgery and/or combination chemotherapy for extraskeletal osteosarcoma: a single-center retrospective study from China
Extraskeletal osteosarcoma (ESOS) is an extremely rare malignancy with poor prognosis, accounting for 2–4% of all osteogenic sarcomas. The purpose of this study was to examine the oncological outcomes of this ...
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Article
Open AccessPhase II trial of VEGFR2 inhibitor apatinib for metastatic sarcoma: focus on efficacy and safety
Apatinib (YN968D1) is a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor receptor 2 (VEGFR-2). We conducted a single-arm, nonrandomized phase II study (NCT03121846) to assess the ef...
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Article
Open AccessRoles of low-density lipoprotein receptor-related protein 1 in tumors
Low-density lipoprotein receptor-related protein 1 (LRP1, also known as CD91), a multifunctional endocytic and cell signaling receptor, is widely expressed on the surface of multiple cell types such as hepatoc...
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Article
Open AccessCorrelation of WWOX, RUNX2 and VEGFA protein expression in human osteosarcoma
To investigate associations between WW domain-containing oxidoreductase (WWOX), runt-related transcription factor 2 (RUNX2) and vascular endothelial growth factor alpha (VEGFA) in human osteosarcoma (OS).
