343 Result(s)

Article

Epigenetic regulation of DNA repair gene program by Hippo/YAP1-TET1 axis mediates sorafenib resistance in HCC

Hepatocellular carcinoma (HCC) is a malignancy that occurs worldwide and is generally associated with poor prognosis. The development of resistance to targeted therapies such as sorafenib is a major challenge ...

Chunli Mo, Weixin You, Yipeng Rao, Zhen** Lin… in Cellular and Molecular Life Sciences (2024)

Article

Clinical efficacy and identification of factors confer resistance to afatinib (tyrosine kinase inhibitor) in EGFR-overexpressing esophageal squamous cell carcinoma

Epidermal growth factor receptor (EGFR) is reportedly overexpressed in most esophageal squamous cell carcinoma (ESCC) patients, but anti-EGFR treatments offer limited survival benefits. Our preclinical data sh...

Yanni Wang, Chang Liu, Huan Chen, ** Jiao… in Signal Transduction and Targeted Therapy (2024)

Article

Combination therapy of KRAS G12V mRNA vaccine and pembrolizumab: clinical benefit in patients with advanced solid tumors

**n**g Wang, Wei Wang, Siyi Zou, Zhiwei Xu, Dan Cao, Shuai Zhang… in Cell Research (2024)

Article

SMAD4 depletion contributes to endocrine resistance by integrating ER and ERBB signaling in HR + HER2− breast cancer

Endocrine resistance poses a significant clinical challenge for patients with hormone receptor-positive and human epithelial growth factor receptor 2-negative (HR + HER2−) breast cancer. Dysregulation of estro...

Kang Li, Dan Shu, Han Li, Ailin Lan, Wenjie Zhang, Zhaofu Tan… in Cell Death & Disease (2024)

Article

Mitochondrial metabolic reprogramming in diabetic kidney disease

Diabetic kidney disease, known as a glomerular disease, arises from a metabolic disorder impairing renal cell function. Mitochondria, crucial organelles, play a key role in substance metabolism via oxidative p...

**aoting Fan, Meilin Yang, Yating Lang, Shangwei Lu, Zhijuan Kong… in Cell Death & Disease (2024)

Article

Tumor initiation and early tumorigenesis: molecular mechanisms and interventional targets

Tumorigenesis is a multistep process, with oncogenic mutations in a normal cell conferring clonal advantage as the initial event. However, despite pervasive somatic mutations and clonal expansion in normal tis...

Shaosen Zhang, **nyi **ao, Yonglin Yi… in Signal Transduction and Targeted Therapy (2024)

Article

DDAH-1 maintains endoplasmic reticulum-mitochondria contacts and protects dopaminergic neurons in Parkinson’s disease

The loss of dopaminergic neurons in the substantia nigra is a hallmark of pathology in Parkinson’s disease (PD). Dimethylarginine dimethylaminohydrolase-1 (DDAH-1) is the critical enzyme responsible for the de...

Yichen Zhao, Weiwei Shen, Minjie Zhang, Min Guo, Yunxiao Dou… in Cell Death & Disease (2024)

Article

CX3CL1-CX3CR1 axis protects retinal ganglion cells by inhibiting microglia activation in a distal optic nerve trauma model

The chemokine CX3CL1 has been reported to play an important role in optic nerve protection, but the underlying mechanism is still unclear. CX3CR1, the only receptor of CX3CL1, is specifically expressed on reti...

Huan Yu, Bingqiao Shen, Ruiqi Han, Yang Zhang, Shushu Xu… in Inflammation and Regeneration (2024)

Article

FBP1 orchestrates keratinocyte proliferation/differentiation and suppresses psoriasis through metabolic control of histone acetylation

Keratinocyte proliferation and differentiation in epidermis are well-controlled and essential for reacting to stimuli such as ultraviolet light. Imbalance between proliferation and differentiation is a charact...

Pengfei Zhang, Ju Yang, **ong Liu, Congshu Huang, Yuandong Tao… in Cell Death & Disease (2024)

Article

Human Amniotic Epithelial Stem Cells Alleviate Autoimmune Premature Ovarian Insufficiency in Mice by Targeting Granulosa Cells via AKT/ERK Pathways

Autoimmune factors play an important role in premature ovarian insufficiency (POI). Human amniotic epithelial stem cells (hAESCs) have recently shown promising treatment effects on chemotherapy-induced POI. Ho...

**aohang Ye, Yifeng Lin, Yanyun Ying, Xuezhi Shen… in Stem Cell Reviews and Reports (2024)

Article

Megakaryocytic IGF1 coordinates activation and ferroptosis to safeguard hematopoietic stem cell regeneration after radiation injury

Hematopoietic stem cell (HSC) regeneration underlies hematopoietic recovery from myelosuppression, which is a life-threatening side effect of cytotoxicity. HSC niche is profoundly disrupted after myelosuppress...

Weinian Liao, **nliang Chen, Shuzhen Zhang, Jun Chen… in Cell Communication and Signaling (2024)

Article

YOD1 protects against MRSA sepsis-induced DIC through Lys33-linked deubiquitination of NLRP3

Disseminated intravascular coagulation (DIC) is considered to be the most common and lethal complication of sepsis. NLR-family pyrin domain-containing-3 (NLRP3) inflammasome plays an important role in host def...

Chang Liu, Caihong Fan, Jia Liu, Shiqi Zhang, Huixin Tang… in Cell Death & Disease (2024)

Article

DEAD-box helicase 17 (DDX17) protects cardiac function by promoting mitochondrial homeostasis in heart failure

DEAD-box helicase 17 (DDX17) is a typical member of the DEAD-box family with transcriptional cofactor activity. Although DDX17 is abundantly expressed in the myocardium, its role in heart is not fully understo...

Ming**g Yan, Junpeng Gao, Ming Lan, Que Wang… in Signal Transduction and Targeted Therapy (2024)

Article

Synergistic effects of Smac mimetic APG-1387 with anti-PD-1 antibody are attributed to increased CD3 + NK1.1 + cell recruitment secondary to induction of cytokines from tumor cells

Immune checkpoint inhibitors are approved for the treatment of various tumors, but the response rate is not satisfactory in certain malignancies. Inhibitor of apoptosis proteins (IAP) ubiquitin-E3 ligase activ...

Wentao Pan, Qiuyun Luo, Eric Liang, Mude Shi, Jian Sun… in Cancer Cell International (2024)

Article

Role of T cells in liver metastasis

The liver is a major metastatic site (organ) for gastrointestinal cancers (such as colorectal, gastric, and pancreatic cancers) as well as non-gastrointestinal cancers (such as lung, breast, and melanoma cance...

Kejia Wu, Guozhu Zhang, Changbing Shen, Li Zhu, Chongyuan Yu… in Cell Death & Disease (2024)

Article

The NTE domain of PTENα/β promotes cancer progression by interacting with WDR5 via its SSSRRSS motif

PTENα/β, two variants of PTEN, play a key role in promoting tumor growth by interacting with WDR5 through their N-terminal extensions (NTEs). This interaction facilitates the recruitment of the SET1/MLL methyl...

**aolei Huang, Cheng Zhang, **nci Shang, Yichang Chen, Qin **ao… in Cell Death & Disease (2024)

Article

A pathological joint–liver axis mediated by matrikine-activated CD4⁺ T cells

The knee joint has long been considered a closed system. The pathological effects of joint diseases on distant organs have not been investigated. Herein, our clinical data showed that post-traumatic joint dama...

Junzhi Yi, Hui Zhang, Fangyuan Bao, Zhichu Chen… in Signal Transduction and Targeted Therapy (2024)

Article

The role of mitochondrial dynamics and mitophagy in skeletal muscle atrophy: from molecular mechanisms to therapeutic insights

Skeletal muscle is the largest metabolic organ of the human body. Maintaining the best quality control and functional integrity of mitochondria is essential for the health of skeletal muscle. However, mitochon...

Yuhang Lei, Mailin Gan, Yanhao Qiu, Qiuyang Chen… in Cellular & Molecular Biology Letters (2024)

Article

ANKFY1 bridges ATG2A-mediated lipid transfer from endosomes to phagophores

Macroautophagy is a process that cells engulf cytosolic materials by autophagosomes and deliver them to lysosomes for degradation. The biogenesis of autophagosomes requires ATG2 as a lipid transfer protein to ...

Bin Wei, Yuhui Fu, **uzhi Li, Fang Chen, Yiqing Zhang, Hanmo Chen… in Cell Discovery (2024)

Article

Increased miR-3074-5p expression promotes M1 polarization and pyroptosis of macrophages via ERα/NLRP3 pathway and induces adverse pregnancy outcomes in mice

Decidual macrophages (dMϕs) play critical roles in regulation of immune-microhomeostasis at maternal-fetal interface during pregnancy, but the underlying molecular mechanisms are still unclear. In this study, ...

Long Yang, Hao-Ran Xu, Xuan Zhang, Yan Shi, Jia-**n Shi… in Cell Death Discovery (2024)