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Article
Open AccessMitochondrial metabolic reprogramming in diabetic kidney disease
Diabetic kidney disease, known as a glomerular disease, arises from a metabolic disorder impairing renal cell function. Mitochondria, crucial organelles, play a key role in substance metabolism via oxidative p...
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Article
Open AccessN6-methyladenosine methylation in kidney injury
Multiple mechanisms are involved in kidney damage, among which the role of epigenetic modifications in the occurrence and development of kidney diseases is constantly being revealed. However, N6-methyladenosin...
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Article
Identification of a CEACAM5 targeted nanobody for positron emission tomography imaging and near-infrared fluorescence imaging of colorectal cancer
Here, we aim to identify a CEACAM5-targeted nanobody and demonstrate its application in positron emission tomography (PET) imaging and near-infrared (NIR) fluorescence imaging in colorectal cancer (CRC).
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Article
Preclinical evaluation of a novel EGFR&c-Met bispecific near infrared probe for visualization of esophageal cancer and metastatic lymph nodes
This study aimed to establish a near infrared fluorescent (NIRF) probe based on an EGFR&c-Met bispecific antibody for visualization of esophageal cancer (EC) and metastatic lymph nodes (mLNs).
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Article
Study on carbon dioxide emission from reservoirs with different regulation types and its empirical prediction model
The construction of artificial reservoirs with various regulation types on river is currently an important form of comprehensive utilization of water energy and water resources in river basins. The type of reg...
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Article
The anaerobic oxidation of methane driven by multiple electron acceptors suppresses the release of methane from the sediments of a reservoir
Methane, produced and emitted when organic carbon accumulates in reservoir sediments, can be oxidised microbially before being released into the overlying water by a variety of electron acceptors. This researc...
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Article
Distribution of functional microorganisms and its significance for iron, sulphur, and nitrogen cycles in reservoir sediments
The biogeochemical cycles of sulphur (S), iron (Fe) and nitrogen (N) elements play a key role in the reservoir ecosystem. However, the spatial positioning and interrelationship of S, Fe and N cycles in the res...
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Article
Tree ring based drought variability in Northwest Tajikistan since 1895 AD
Determining the mechanisms controlling the changes of wet and dry conditions will improve our understanding of climate change over the past hundred years, which is of great significance to the study of climate...
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Article
Improvement of X-Band Polarization Radar Melting Layer Recognition by the Bayesian Method and ITS Impact on Hydrometeor Classification
Using melting layer (ML) and non-melting layer (NML) data observed with the X-band dual linear polarization Doppler weather radar (X-POL) in Shunyi, Bei**g, the reflectivity (ZH), differential reflectivity (ZDR)...
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Article
The effect of future reduction in aerosol emissions on climate extremes in China
This study investigates the effect of reduced aerosol emissions on projected temperature and precipitation extremes in China during 2031–2050 and 2081–2100 relative to present-day conditions using the daily da...
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Article
Salinomycin radiosensitizes human nasopharyngeal carcinoma cell line CNE-2 to radiation
Nasopharyngeal carcinoma (NPC) is primarily treated by chemoradiation. However, how to promote radiation sensitivity in NPC remains a challenge. Salinomycin is potentially useful for the treatment of cancer. T...
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Article
Genome-wide association pathway analysis to identify candidate single nucleotide polymorphisms and molecular pathways for gastric adenocarcinoma
To demonstrate candidate single nucleotide polymorphisms that might affect susceptibility to gastric adenocarcinoma as well as their potential mechanisms and pathway hypotheses, we performed a genome-wide asso...
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Article
An improved method for correction of air temperature measured using different radiation shields
The variation of air temperature measurement errors using two different radiation shields (DTR502B Vaisala, Finland, and HYTFZ01, Huayun Tongda Satcom, China) was studied. Datasets were collected in the field ...
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Article
Open AccessTissue distribution of emulsified γ-tocotrienol and its long-term biological effects after subcutaneous administration
γ-tocotrienol (GT3), an analogue of vitamin E, has gained increasing scientific interest recently as it provides significant health benefits. It has been shown that emulsified GT3, after subcutaneous administr...
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Article
The discovery of annually laminated sediments (varves) from shallow Sugan Lake in inland arid China and their paleoclimatic significance
Detailed examination of sedimentary cores retrieved from Sugan Lake in the northern Qaidam Basin of northwest China’s Tibetan Plateau reveal that fine laminated beddings form in the sediments where water depth...
