451 Result(s)

Article

Epigenetic regulation of DNA repair gene program by Hippo/YAP1-TET1 axis mediates sorafenib resistance in HCC

Hepatocellular carcinoma (HCC) is a malignancy that occurs worldwide and is generally associated with poor prognosis. The development of resistance to targeted therapies such as sorafenib is a major challenge ...

Chunli Mo, Weixin You, Yipeng Rao, Zhen** Lin… in Cellular and Molecular Life Sciences (2024)

Article

Biofilm-producing ability of methicillin-resistant Staphylococcus aureus clinically isolated in China

Staphylococcus aureus, a commensal bacterium, colonizes the skin and mucous membranes of approximately 30% of the human population. Apart from conventional resistance mechanisms, one of the pathogenic features of...

**gyi Yu, Weihua Han, Yanlei Xu, Li Shen, Huilin Zhao, Jiao Zhang… in BMC Microbiology (2024)

Article

Combination therapy of KRAS G12V mRNA vaccine and pembrolizumab: clinical benefit in patients with advanced solid tumors

**n**g Wang, Wei Wang, Siyi Zou, Zhiwei Xu, Dan Cao, Shuai Zhang… in Cell Research (2024)

Article

SMAD4 depletion contributes to endocrine resistance by integrating ER and ERBB signaling in HR + HER2− breast cancer

Endocrine resistance poses a significant clinical challenge for patients with hormone receptor-positive and human epithelial growth factor receptor 2-negative (HR + HER2−) breast cancer. Dysregulation of estro...

Kang Li, Dan Shu, Han Li, Ailin Lan, Wenjie Zhang, Zhaofu Tan… in Cell Death & Disease (2024)

Article

Mitochondrial metabolic reprogramming in diabetic kidney disease

Diabetic kidney disease, known as a glomerular disease, arises from a metabolic disorder impairing renal cell function. Mitochondria, crucial organelles, play a key role in substance metabolism via oxidative p...

**aoting Fan, Meilin Yang, Yating Lang, Shangwei Lu, Zhijuan Kong… in Cell Death & Disease (2024)

Article

Octanoic acid mitigates busulfan-induced blood-testis barrier damage by alleviating oxidative stress and autophagy

The management of male infertility continues to encounter an array of challenges and constraints, necessitating an in-depth exploration of novel therapeutic targets to enhance its efficacy. As an eight-carbon ...

Chun Cao, Hong Zhang, Zhaowanyue He, Kemei Zhang… in Lipids in Health and Disease (2024)

Article

Hypoxia-induced activation of HIF-1alpha/IL-1beta axis in microglia promotes glioma progression via NF-κB-mediated upregulation of heparanase expression

Glioma is a common tumor that occurs in the brain and spinal cord. Hypoxia is a crucial feature of the tumor microenvironment. Tumor-associated macrophages/microglia play a crucial role in the advancement of g...

**chao Si, **gya Guo, Xu Zhang, Wei Li, Shen Zhang, Shuyu Shang… in Biology Direct (2024)

Article

DDAH-1 maintains endoplasmic reticulum-mitochondria contacts and protects dopaminergic neurons in Parkinson’s disease

The loss of dopaminergic neurons in the substantia nigra is a hallmark of pathology in Parkinson’s disease (PD). Dimethylarginine dimethylaminohydrolase-1 (DDAH-1) is the critical enzyme responsible for the de...

Yichen Zhao, Weiwei Shen, Minjie Zhang, Min Guo, Yunxiao Dou… in Cell Death & Disease (2024)

Article

FBP1 orchestrates keratinocyte proliferation/differentiation and suppresses psoriasis through metabolic control of histone acetylation

Keratinocyte proliferation and differentiation in epidermis are well-controlled and essential for reacting to stimuli such as ultraviolet light. Imbalance between proliferation and differentiation is a charact...

Pengfei Zhang, Ju Yang, **ong Liu, Congshu Huang, Yuandong Tao… in Cell Death & Disease (2024)

Article

Human Amniotic Epithelial Stem Cells Alleviate Autoimmune Premature Ovarian Insufficiency in Mice by Targeting Granulosa Cells via AKT/ERK Pathways

Autoimmune factors play an important role in premature ovarian insufficiency (POI). Human amniotic epithelial stem cells (hAESCs) have recently shown promising treatment effects on chemotherapy-induced POI. Ho...

**aohang Ye, Yifeng Lin, Yanyun Ying, Xuezhi Shen… in Stem Cell Reviews and Reports (2024)

Article

Integrative genomic and transcriptomic analysis of Xanthomonas oryzae pv. oryzae pathotype IV, V, and IX in China reveals rice defense-responsive genes

Bacterial blight of rice is a devastating disease caused by the gram-negative bacteria Xanthomonas oryzae pv. oryzae (Xoo). Chinese Xoo strain pathotypes IV, V, and IX are the major virulent Xoo strain types in S...

Zecong Li, Shujuan Shen, Kuaifei **a, Mingyong Zhang, Xuan Zeng in Phytopathology Research (2024)

Article

Megakaryocytic IGF1 coordinates activation and ferroptosis to safeguard hematopoietic stem cell regeneration after radiation injury

Hematopoietic stem cell (HSC) regeneration underlies hematopoietic recovery from myelosuppression, which is a life-threatening side effect of cytotoxicity. HSC niche is profoundly disrupted after myelosuppress...

Weinian Liao, **nliang Chen, Shuzhen Zhang, Jun Chen… in Cell Communication and Signaling (2024)

Article

YOD1 protects against MRSA sepsis-induced DIC through Lys33-linked deubiquitination of NLRP3

Disseminated intravascular coagulation (DIC) is considered to be the most common and lethal complication of sepsis. NLR-family pyrin domain-containing-3 (NLRP3) inflammasome plays an important role in host def...

Chang Liu, Caihong Fan, Jia Liu, Shiqi Zhang, Huixin Tang… in Cell Death & Disease (2024)

Article

Role of T cells in liver metastasis

The liver is a major metastatic site (organ) for gastrointestinal cancers (such as colorectal, gastric, and pancreatic cancers) as well as non-gastrointestinal cancers (such as lung, breast, and melanoma cance...

Kejia Wu, Guozhu Zhang, Changbing Shen, Li Zhu, Chongyuan Yu… in Cell Death & Disease (2024)

Article

The NTE domain of PTENα/β promotes cancer progression by interacting with WDR5 via its SSSRRSS motif

PTENα/β, two variants of PTEN, play a key role in promoting tumor growth by interacting with WDR5 through their N-terminal extensions (NTEs). This interaction facilitates the recruitment of the SET1/MLL methyl...

**aolei Huang, Cheng Zhang, **nci Shang, Yichang Chen, Qin **ao… in Cell Death & Disease (2024)

Article

4D label-free proteomics analysis of oxygen-induced retinopathy with or without anti-VEGF treatment

Oxygen-induced retinopathy (OIR) animal model is widely used for retinopathy of prematurity (ROP) researches. The purpose of this study was to identify proteins and related pathways of OIR with or without anti...

Zhaokai Xu, Yubo Wu, Jianbo Mao, Yiqi Chen, Huan Chen, Shian Zhang… in BMC Genomics (2024)

Article

The role of mitochondrial dynamics and mitophagy in skeletal muscle atrophy: from molecular mechanisms to therapeutic insights

Skeletal muscle is the largest metabolic organ of the human body. Maintaining the best quality control and functional integrity of mitochondria is essential for the health of skeletal muscle. However, mitochon...

Yuhang Lei, Mailin Gan, Yanhao Qiu, Qiuyang Chen… in Cellular & Molecular Biology Letters (2024)

Article

Natural GmACO1 allelic variations confer drought tolerance and influence nodule formation in soybean

Soybean [Glycine max (L.) Merr.] is one of the most important, but a drought-sensitive, crops. Identifying the genes controlling drought tolerance is important in soybean breeding. Here, through a genome-wide ass...

Zhifang Zhang, Junkui Ma, **a Yang, Shan Liang, Yucheng Liu, Yaqin Yuan… in aBIOTECH (2024)

Article

ANKFY1 bridges ATG2A-mediated lipid transfer from endosomes to phagophores

Macroautophagy is a process that cells engulf cytosolic materials by autophagosomes and deliver them to lysosomes for degradation. The biogenesis of autophagosomes requires ATG2 as a lipid transfer protein to ...

Bin Wei, Yuhui Fu, **uzhi Li, Fang Chen, Yiqing Zhang, Hanmo Chen… in Cell Discovery (2024)

Article

Allantoate Amidohydrolase OsAAH is Essential for Preharvest Sprouting Resistance in Rice

Preharvest sprouting (PHS) is an undesirable trait that decreases yield and quality in rice production. Understanding the genes and regulatory mechanisms underlying PHS is of great significance for breeding PH...

Ting **e, Wenling Hu, Jiaxin Shen, Jiangyu Xu, Zeyuan Yang, **nyi Chen, Peiwen Zhu… in Rice (2024)