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Reference Work Entry In depth
Enterohemorrhagic E. coli (EHEC): Environmental-Vehicle-Human Interface
Enterohemorrhagic Escherichia coli (EHEC) are a pathogenic subgroup of Shiga toxin-producing E. coli (STEC) that can cause severe intestinal disease and hemolytic uremic syndrome (HUS) in humans, the latter of wh...
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Living Reference Work Entry In depth
Enterohemorrhagic E. coli (EHEC): Environmental-Vehicle-Human Interface
Enterohemorrhagic Escherichia coli (EHEC) are a pathogenic subgroup of Shiga toxin-producing E. coli (STEC) that can cause severe intestinal disease and hemolytic uremic syndrome (HUS) in humans, the latter of wh...
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Article
Open AccessEvaluation of 16S rRNA gene sequencing for species and strain-level microbiome analysis
The 16S rRNA gene has been a mainstay of sequence-based bacterial analysis for decades. However, high-throughput sequencing of the full gene has only recently become a realistic prospect. Here, we use in silic...
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Article
A longitudinal big data approach for precision health
Precision health relies on the ability to assess disease risk at an individual level, detect early preclinical conditions and initiate preventive strategies. Recent technological advances in omics and wearable...
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Article
Open AccessLongitudinal multi-omics of host–microbe dynamics in prediabetes
Type 2 diabetes mellitus (T2D) is a growing health problem, but little is known about its early disease stages, its effects on biological processes or the transition to clinical T2D. To understand the earliest...
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Chapter
Enterohemorrhagic E. coli (EHEC): Environmental-Vehicle-Human Interface
Enterohemorrhagic Escherichia coli (EHEC) are a pathogenic subgroup of Shiga toxin-producing E. coli (STEC), and have demonstrated ability to cause severe intestinal disease and the hemolytic uremic syndrome (HUS...
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Article
Intestinal damage in enterohemorrhagic Escherichia coli infection
Enterohemorrhagic Escherichia coli (EHEC) infection leads to marked intestinal injury. Sigmoid colon obtained from two children during EHEC infection exhibited abundant TUNEL-positive cells. To define which bacte...
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Article
Open AccessObscured phylogeny and possible recombinational dormancy in Escherichia coli
Escherichia coli is one of the best studied organisms in all of biology, but its phylogenetic structure has been difficult to resolve with current data and analytical techniques. We analyzed single nucleotide pol...
