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Article
Open AccessNisin probiotic prevents inflammatory bone loss while promoting reparative proliferation and a healthy microbiome
Dysbiosis of the oral microbiome mediates chronic periodontal disease. Realignment of microbial dysbiosis towards health may prevent disease. Treatment with antibiotics and probiotics can modulate the microbia...
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Article
Open AccessDeep longitudinal multiomics profiling reveals two biological seasonal patterns in California
The influence of seasons on biological processes is poorly understood. In order to identify biological seasonal patterns based on diverse molecular data, rather than calendar dates, we performed a deep longitu...
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Article
Open AccessMulti-faceted epigenetic dysregulation of gene expression promotes esophageal squamous cell carcinoma
Epigenetic landscapes can shape physiologic and disease phenotypes. We used integrative, high resolution multi-omics methods to delineate the methylome landscape and characterize the oncogenic drivers of esoph...
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Article
Open AccessPolymicrobial periodontal disease triggers a wide radius of effect and unique virome
Periodontal disease is a microbially-mediated inflammatory disease of tooth-supporting tissues that leads to bone and tissue loss around teeth. Although bacterially-mediated mechanisms of alveolar bone destruc...
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Article
Personal aging markers and ageotypes revealed by deep longitudinal profiling
The molecular changes that occur with aging are not well understood1–4. Here, we performed longitudinal and deep multiomics profiling of 106 healthy individuals from 29 to 75 years of age and examined how differe...
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Article
A longitudinal big data approach for precision health
Precision health relies on the ability to assess disease risk at an individual level, detect early preclinical conditions and initiate preventive strategies. Recent technological advances in omics and wearable...
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Article
Open AccessLongitudinal multi-omics of host–microbe dynamics in prediabetes
Type 2 diabetes mellitus (T2D) is a growing health problem, but little is known about its early disease stages, its effects on biological processes or the transition to clinical T2D. To understand the earliest...
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Open AccessLifelong physical activity is associated with promoter hypomethylation of genes involved in metabolism, myogenesis, contractile properties and oxidative stress resistance in aged human skeletal muscle
Lifelong regular physical activity is associated with reduced risk of type 2 diabetes (T2D), maintenance of muscle mass and increased metabolic capacity. However, little is known about epigenetic mechanisms th...
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Article
Open AccessCircular DNA elements of chromosomal origin are common in healthy human somatic tissue
The human genome is generally organized into stable chromosomes, and only tumor cells are known to accumulate kilobase (kb)-sized extrachromosomal circular DNA elements (eccDNAs). However, it must be expected ...
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Article
Open AccessIsolated Congenital Anosmia and CNGA2 Mutation
Isolated congenital anosmia (ICA) is a rare condition that is associated with life-long inability to smell. Here we report a genetic characterization of a large Iranian family segregating ICA. Whole exome sequ...
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Article
Association of AHSG with alopecia and mental retardation (APMR) syndrome
Alopecia with mental retardation syndrome (APMR) is a very rare autosomal recessive condition that is associated with total or partial absence of hair from the scalp and other parts of the body as well as vari...
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Article
Correction: Corrigendum: Domains of genome-wide gene expression dysregulation in Down’s syndrome
Nature 508, 345–350 (2014); doi:10.1038/nature13200 Owing to a labelling error in the input files, one of the two replicate data sets used for Fig. 5d and e and Supplementary Fig. 6d of this Article was incorr...
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Domains of genome-wide gene expression dysregulation in Down’s syndrome
Trisomy 21 is the most frequent genetic cause of cognitive impairment. To assess the perturbations of gene expression in trisomy 21, and to eliminate the noise of genomic variability, we studied the transcript...
