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  1. Article

    Towards the development of phytoextract based healthy ageing cognitive booster formulation, explored through Caenorhabditis elegans model

    The positive effect of herbal supplements on aging and age-related disorders has led to the evolution of natural curatives for remedial neurodegenerative diseases in humans. The advancement in aging is exceedi...

    Rakesh Pandey, Dayanandan Mani, Karuna Shanker, Dnyaneshwar Umrao Bawankule… in The Nucleus (2022)

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    5′-Hydroxy-6, 7, 8, 3′, 4′-pentamethoxyflavone extends longevity mediated by DR-induced autophagy and oxidative stress resistance in C. elegans

    5′-Hydroxy-6, 7, 8, 3′, 4′-pentamethoxyflavone (5-HPF), a polymethoxyflavone compound found in dikamali gum, has been shown to exert a range of beneficial effects on health. We have previously reported that 5-...

    Shalini Trivedi, Rakesh Pandey in GeroScience (2021)

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    Wedelolactone Mitigates Parkinsonism Via Alleviating Oxidative Stress and Mitochondrial Dysfunction Through NRF2/SKN-1

    Parkinsonism is an age-associated neurodegenerative disorder characterized by aggregation of α-synuclein (α-syn) protein in the substantia nigra region, degeneration of dopaminergic neurons, and deregulated li...

    Shruti Sharma, Shalini Trivedi, Taruna Pandey, Sachin Ranjan… in Molecular Neurobiology (2021)

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    A Bioactive compound Shatavarin IV-mediated longevity as revealed by dietary restriction-induced autophagy in Caenorhabditis elegans

    Plant-based dietary supplements that delay aging are of significant interest now a days because these naturally occurring bioactive molecules effectively provide pharmaceuticals/neutraceuticals to deal with di...

    Shachi Shuchi Smita, Shalini Trivedi, Taruna Pandey, Mashu Trivedi… in Biogerontology (2020)

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    Trachyspermum ammi L. (Carom) Oil Induces Alterations in SOD-3, GST-4 Expression and Prolongs Lifespan in Caenorhabditis elegans

    The use of herbs in the form of dietary supplements and medicine is fascinating the world, owing to their safety and protective effects against oxidative stress. The elevation in oxidative stress promotes agin...

    Laxmi Rathor, Aakanksha Pant, Abhishek Nagar… in Proceedings of the National Academy of Sci… (2017)

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    1-Methyl-4-propan-2-ylbenzene from Thymus vulgaris Attenuates Cholinergic Dysfunction

    Cholinergic dysfunction is manifested in a plethora of neurodegenerative and psychiatric disorders such as Alzheimer’s, Parkinson’s, and Huntington’s diseases. The extent of cholinergic affliction is maximum i...

    Shreesh Raj Sammi, Shalini Trivedi, Srikanta Kumar Rath… in Molecular Neurobiology (2017)