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Article
Changes in expression of breast cancer tumor biomarkers between primary tumors and corresponding metastatic sites: common patterns and relationships with survival
In metastatic breast cancer, differences in expression patterns of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor-2 (HER2) between the primary tumor (PT) and met...
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Chapter and Conference Paper
Multi-agent Deception in Attack-Defense Stochastic Game
This paper studies a sequential adversarial incomplete information game, the attack-defense game, with multiple defenders against one attacker. The attacker has limited information on game configurations and m...
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Article
Open AccessProtective effect of Insect tea primary leaf (Malus sieboldii (Regal) Rehd.) extract on H2O2-induced oxidative damage in human embryonic kidney 293T cells
In this study, Insect tea primary leaf (Malus sieboldii (Regal) Rehd.) was used as the research object to investigate the protective effect of Insect tea primary extract (ITPLE) on hydrogen peroxide (H2O2)-induce...
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Chapter and Conference Paper
Indoor Pursuit-Evasion with Hybrid Hierarchical Partially Observable Markov Decision Processes for Multi-robot Systems
In this paper, we examine a pursuit-evasion problem where more than one pursuer may search for one evader in indoor environments. Partially Observable Markov Decision Processes (POMDPs) provide a framework to ...
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Article
Enhanced hydrogen evolution properties obtained by ultrasonic-cyclic voltammetry modification of C-supported PtCu thin film catalyst
Carbon-supported Pt-Cu (Pt-Cu/C) bimetallic catalyst was synthesized by Ion Beam Sputtering technology and subsequently annealed in vacuum and electrochemically etched by Ultrasonic-Cyclic Voltammetry (US-CV)....
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Article
Open AccessInhibition of MDM2 homodimerization by XIAP IRES stabilizes MDM2, influencing cancer cell survival
It is known that the MDM2 protein is stabilized when it forms a heterodimer with its partner MDM4, but MDM2 protein stability in its homodimer form is not known. The MDM2 protein contains a C-terminal RING dom...
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Article
Deguelin, a selective silencer of the NPM1 mutant, potentiates apoptosis and induces differentiation in AML cells carrying the NPM1 mutation
Nucleophosmin (NPM1) is a multifunctional protein that functions as a molecular chaperone, shuttling between the nucleolus and the cytoplasm. In up to one third of patients with acute myeloid leukemia, mutatio...
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Article
Oridonin induces NPM mutant protein translocation and apoptosis in NPM1c+ acute myeloid leukemia cells in vitro
Skewed cytoplasmic accumulation of NPM mutant protein (NPM1c+) is close related to leukemia pathogenesis. The aim of this study was to investigate whether oridonin, a diterpenoid isolated from the Chinese trad...
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Article
Betulinic acid inhibits autophagic flux and induces apoptosis in human multiple myeloma cells in vitro
To investigate the effects of betulinic acid (BA) on apoptosis and autophagic flux in multiple myeloma cells and the relationship between the two processes.
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Article
The time-dependent autophagy protects against apoptosis with possible involvement of Sirt1 protein in multiple myeloma under nutrient depletion
The absence of researches about autophagy in multiple myeloma promoted us to explore the biological characteristics and role of autophagy induced by nutrient depletion in multiple myeloma (MM) cell line RPMI82...
