-
Article
Open AccessGenoMycAnalyzer: a web-based tool for species and drug resistance prediction for Mycobacterium genomes
Drug-resistant tuberculosis (TB) is a major threat to global public health. Whole-genome sequencing (WGS) is a useful tool for species identification and drug resistance prediction, and many clinical laborator...
-
Article
Open AccessSpatial architectures of somatic mutations in normal prostate, benign prostatic hyperplasia and coexisting prostate cancer
This study aimed to identify somatic mutations in nontumor cells (NSMs) in normal prostate and benign prostatic hyperplasia (BPH) and to determine their relatedness to prostate cancer (PCA). From 22 PCA patien...
-
Article
Open AccessSingle-cell analysis of multiple myelomas refines the molecular features of bortezomib treatment responsiveness
Both the tumor and tumor microenvironment (TME) are crucial for pathogenesis and chemotherapy resistance in multiple myeloma (MM). Bortezomib, commonly used for MM treatment, works on both MM and TME cells, bu...
-
Article
Open AccessSpatiotemporal dynamics of macrophage heterogeneity and a potential function of Trem2hi macrophages in infarcted hearts
Heart failure (HF) is a frequent consequence of myocardial infarction (MI). Identification of the precise, time-dependent composition of inflammatory cells may provide clues for the establishment of new biomar...
-
Article
High Prevalence of DICER1 Mutations and Low Frequency of Gene Fusions in Pediatric Follicular-Patterned Tumors of the Thyroid
Follicular-patterned tumors of the thyroid in the adult population frequently harbor RAS mutations or PAX8-PPARG rearrangement, but little is known about molecular profiles in the pediatric patients with thyroid ...
-
Article
Open AccessUrinary exosome microRNA signatures as a noninvasive prognostic biomarker for prostate cancer
Predicting the risk of metastasis before starting prostate cancer (PCa) treatment can minimize the overtreatment of indolent cases and help choosing appropriate treatment. The levels of circulating microRNAs (...
-
Article
Open AccessDistinct genomic profiles of gestational choriocarcinoma, a unique cancer of pregnant tissues
Little is known about genomic alterations of gestational choriocarcinoma (GC), unique cancer that originates in pregnant tissues, and the progression mechanisms from the nonmalignant complete hydatidiform mole...
-
Article
Open AccessPathogenic NF1 truncating mutation and copy number alterations in a dedifferentiated liposarcoma with multiple lung metastasis: a case report
Dedifferentiated liposarcoma (DDLPS), which accounts for an estimated 15–20% of liposarcomas, is a high-grade and aggressive malignant neoplasm, exhibiting a poor response to available therapeutic agents. Howe...
-
Article
Open AccessAuthor Correction: Highly pathogenic H5N6 avian influenza virus subtype clade 2.3.4.4 indigenous in South Korea
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
-
Article
Open AccessHighly pathogenic H5N6 avian influenza virus subtype clade 2.3.4.4 indigenous in South Korea
The outbreaks of the highly pathogenic avian influenza (HPAI) in 2016–2017 and 2017–2018, caused by novel reassortant clade 2.3.4.4 H5N6 viruses, resulted in the loss of one billion birds in South Korea. Here,...
-
Article
Combining Stochastic Adaptive Cubic Regularization with Negative Curvature for Nonconvex Optimization
We focus on minimizing nonconvex finite-sum functions that typically arise in machine learning problems. In an attempt to solve this problem, the adaptive cubic-regularized Newton method has shown its strong g...
-
Article
Association of HK2 and NCK2 with normal-tension glaucoma in a population from the Republic of Korea
Previous studies have reported the association of HK2 and NCK2 genes with normal-tension glaucoma (NTG) in Japan, but there has been no follow-up study in other countries, so the relevance of these genes to NTG a...
-
Article
Open AccessElectroacupuncture to treat with Overactive Bladder in Postmenopausal Women: study protocol for a multicenter, randomized, controlled, parallel clinical trial
Electroacupuncture has been used for treatment in patients with overactive bladder. This study was conducted to evaluate the efficacy and safety of electroacupuncture for treating overactive bladder of postmen...
-
Article
Open AccessOverexpression of TFF3 is involved in prostate carcinogenesis via blocking mitochondria-mediated apoptosis
The overexpression of trefoil factor family 3 (TFF3) is observed in a variety of cancers, including prostate cancer (PCa), and its potential role in carcinogenesis, such as activating the PI3K/AKT pathway, is ...
-
Article
Open AccessMutational signatures and chromosome alteration profiles of squamous cell carcinomas of the vulva
Vulvar squamous cell carcinoma (SCC) consists of two different etiologic categories: human papilloma virus (HPV)-associated (HPV (+)) and HPV-non-associated (HPV (−)). There have been no genome-wide studies on...
-
Article
Open AccessSilencing of KIF14 interferes with cell cycle progression and cytokinesis by blocking the p27Kip1 ubiquitination pathway in hepatocellular carcinoma
Although it has been suggested that kinesin family member 14 (KIF14) has oncogenic potential in various cancers, including hepatocellular carcinoma (HCC), the molecular mechanism of this potential remains unkn...
-
Article
Open AccessDe novo copy number variations in cloned dogs from the same nuclear donor
Somatic mosaicism of copy number variants (CNVs) in human body organs and de novo CNV event in monozygotic twins suggest that de novo CNVs can occur during mitotic recombination. These de novo CNV events are i...
-
Article
Herb mixture C5E aggravates doxorubicin-induced apoptosis of human breast cancer cell lines
A number of extracts from Asian traditional medicinal herbs have been successfully used as therapeutic agents against cancers. In this study we assessed the effect of C5E on the proliferation inhibition and ap...
-
Article
Establishment of a bone-specific col10a1:GFP transgenic zebrafish
During skeletal development, both osteogenic and chondrogenic programs are initiated from multipotent mesenchymal cells, requiring a number of signaling molecules, transcription factors, and downstream effecto...
-
Article
A1E inhibits proliferation and induces apoptosis in NCI-H460 lung cancer cells via extrinsic and intrinsic pathways
It has been reported that extracts from Asian traditional/medical herbs possess therapeutic agents against cancers, metabolic diseases, inflammatory diseases, and other intractable diseases. In this study, we ...
