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Protocol
Application of Array Comparative Genomic Hybridization in Chronic Myeloid Leukemia
Chromosomal alteration is one of the hallmarks of chronic myeloid leukemia (CML), and the Philadelphia chromosome is the most important and key example of the chromosomal changes in this disease. Indeed, the BCR–
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Article
Open AccessSimultaneous copy number gains of NUPR1 and ERBB2 predicting poor prognosis in early-stage breast cancer
The full extent of chromosomal alterations and their biological implications in early breast carcinogenesis has not been well examined. In this study, we aimed to identify chromosomal alterations associated wi...
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Article
Her4-positive population in the tectum opticum is proliferating neural precursors in the adult zebrafish brain
Previous studies have shown that Notch signaling not only regulates the number of early differentiating neurons, but also maintains proliferating neural precursors in the neural tube. Although it is well known...
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Article
In vitro and in vivo osteogenic activity of licochalcone A
We investigated the in vitro and in vivo osteogenic activity of licochalcone A. At low concentrations, licochalcone A stimulated the differentiation of mouse pre-osteoblastic MC3T3-E1 subclone 4 (MC4) cells an...
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Article
Open AccessCommon variants at the promoter region of the APOM confer a risk of rheumatoid arthritis
Although the genetic component in the etiology of rheumatoid arthritis (RA) has been consistently suggested, many novel genetic loci remain to uncover. To identify RA risk loci, we performed a genome-wide asso...
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Article
Open AccessCug2 is essential for normal mitotic control and CNS development in zebrafish
We recently identified a novel oncogene, Cancer-upregulated gene 2 (CUG2), which is essential for kinetochore formation and promotes tumorigenesis in mammalian cells. However, the in vivo function of CUG2 has ...
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Chapter and Conference Paper
A Vertical Search Engine for School Information Based on Heritrix and Lucene
The contents on the web are increasing exponentially as the rapid development of the Internet applications and services continues to expand. A problem in obtaining useful information from vast contents quickly...
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Article
Open AccessTropomyosin3 overexpression and a potential link to epithelial-mesenchymal transition in human hepatocellular carcinoma
Since hepatocellular carcinoma (HCC) is one of the leading causes of cancer death worldwide, it is still important to understand hepatocarcinogenesis mechanisms and identify effective markers for tumor progres...
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Article
Open AccessIntegrated analysis of copy number alteration and RNA expression profiles of cancer using a high-resolution whole-genome oligonucleotide array
Recently, microarray-based comparative genomic hybridization (array-CGH) has emerged as a very efficient technology with higher resolution for the genome-wide identification of copy number alterations (CNA). A...
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Article
Open AccessImplication of leucyl-tRNA synthetase 1 (LARS1) over-expression in growth and migration of lung cancer cells detected by siRNA targeted knock-down analysis
Molecular mechanism of lung carcinogenesis and its aggressive nature is still largely elusive. To uncover the biomarkers related with tumorigenesis and behavior of lung cancer, we screened novel differentially...
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Article
Hepatic Abscess That Formed Secondary to Fish Bone and Had a Fistula With the Ascending Colon
We present the case of a liver abscess that formed secondary to foreign bodies and formed a fistula the ascending colon and was successfully treated with percutaneous abscess drainage and colonoscopic removal ...
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Chapter and Conference Paper
SPDBS: An SBML-Based Biochemical Pathway Database System
Biochemical pathways such as metabolic, regulatory, or signal transduction pathways can be viewed as a complicated network of interactions among molecular species in the cell. As the amount of pathway informat...
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Chapter and Conference Paper
An Efficient Storage Model for the SBML Documents Using Object Databases
As SBML is regarded as a de-facto standard to express the biological network data in systems biology, the amount of the SBML documents is exponentially increasing. We propose an SBML data management system (SM...
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Article
Structure-related cytotoxicity and anti-hepatofibric effect of asiatic acid derivatives in rat hepatic stellate cell-line, HSC-T6
The structural relationship of 16 asiatic acid (AA) derivatives, including AA and asiaticoside (AS) to cytotoxicity and anti-hepatofibrotic activity in HSC-T6 cells, were investigated. Cytotoxicities of AA der...
