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Article
Open AccessPathologic tau conformer ensembles induce dynamic, liquid-liquid phase separation events at the nuclear envelope
The microtubule-associated protein tau forms aggregates in different neurodegenerative diseases called tauopathies. Prior work has shown that a single P301L mutation in tau gene, MAPT, can promote alternative tau...
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Article
Correction to: Diverse, evolving conformer populations drive distinct phenotypes in frontotemporal lobar degeneration caused by the same MAPT‑P301L mutation
In the original publication, Table 1 column heads are incorrectly formatted and aligned. The corrected Table 1 is given here.
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Article
Open AccessDiverse, evolving conformer populations drive distinct phenotypes in frontotemporal lobar degeneration caused by the same MAPT-P301L mutation
Tau protein accumulation is a common denominator of major dementias, but this process is inhomogeneous, even when triggered by the same germline mutation. We considered stochastic misfolding of human tau confo...
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Chapter
The PrP-Like Proteins Shadoo and Doppel
An almost unique place within protein databases, twenty-five years of study has underscored the enigmatically subtle role of PrPC in normal cell biology. It seems that PrP has evolved (and survived) to perform a ...
