-
Article
Prion-like strain effects in tauopathies
Tau is a microtubule-associated protein that plays crucial roles in physiology and pathophysiology. In the realm of dementia, tau protein misfolding is associated with a wide spectrum of clinicopathologically ...
-
Article
Open AccessPathologic tau conformer ensembles induce dynamic, liquid-liquid phase separation events at the nuclear envelope
The microtubule-associated protein tau forms aggregates in different neurodegenerative diseases called tauopathies. Prior work has shown that a single P301L mutation in tau gene, MAPT, can promote alternative tau...
-
Article
Correction to: Diverse, evolving conformer populations drive distinct phenotypes in frontotemporal lobar degeneration caused by the same MAPT‑P301L mutation
In the original publication, Table 1 column heads are incorrectly formatted and aligned. The corrected Table 1 is given here.
-
Article
Open AccessDiverse, evolving conformer populations drive distinct phenotypes in frontotemporal lobar degeneration caused by the same MAPT-P301L mutation
Tau protein accumulation is a common denominator of major dementias, but this process is inhomogeneous, even when triggered by the same germline mutation. We considered stochastic misfolding of human tau confo...
-
Article
Corrosion resistance and antibacterial effects of hydroxyapatite coating induced by polyacrylic acid and gentamicin sulfate on magnesium alloy
Magnesium (Mg) alloys have attracted considerable research attention as potential biocompatible implant materials. However, the major barriers to the extended use of such medical devices are the possibility of...
