38 Result(s)
within
Seong-** Yu
English
Neurosciences
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Article
Open AccessIntravitreal ranibizumab injection is associated with an increased risk of chronic kidney disease: a population-based study in Taiwan
Systemic vascular endothelial growth factor (VEGF) blockade has been the top adjunctive chemotherapy since 1990. Anti-VEGF therapy has also been associated with worsened renal function in some patients. Howeve...
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Open AccessChronic unpredictable stress induces autophagic death of adult hippocampal neural stem cells
Chronic psychological stress is a critical factor for neurological complications like anxiety disorders, dementia, and depression. Our previous results show that chronic restraint stress causes cognitive defic...
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Interpersonal sensitivity and childhood trauma in patients with major depressive disorder, bipolar I, and II disorder
Childhood trauma and interpersonal sensitivity impact the development of mood disorders. In this study, we investigate the association between childhood trauma and interpersonal sensitivity in patients with mo...
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Open AccessDistinct effects of cholesterol profile components on amyloid and vascular burdens
Cholesterol plays important roles in β-amyloid (Aβ) metabolism and atherosclerosis. However, the relationships of plasma cholesterol levels with Aβ and cerebral small vessel disease (CSVD) burdens are not full...
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Open AccessRisk of dementia in primary aldosteronism compared with essential hypertension: a nationwide cohort study
Although hypertension is a critical risk factor for dementia, the association between primary aldosteronism (PA) and dementia has been scarcely reported. We aimed to investigate whether the risk of dementia in...
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Open AccessExtrasynaptic NMDA receptors in acute and chronic excitotoxicity: implications for preventive treatments of ischemic stroke and late-onset Alzheimer’s disease
Stroke and late-onset Alzheimer’s disease (AD) are risk factors for each other; the comorbidity of these brain disorders in aging individuals represents a significant challenge in basic research and clinical p...
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Optic disc edema as a sole manifestation of anti-GQ1b antibody syndrome
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δ-Secretase-cleaved Tau stimulates Aβ production via upregulating STAT1-BACE1 signaling in Alzheimer’s disease
δ-Secretase, an age-dependent asparagine protease, cleaves both amyloid precursor protein (APP) and Tau and is required for amyloid plaque and neurofibrillary tangle pathologies in Alzheimer’s disease (AD). Ho...
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Open AccessGenetic associations of in vivo pathology influence Alzheimer’s disease susceptibility
Although the heritability of sporadic Alzheimer’s disease (AD) is estimated to be 60–80%, addressing the genetic contribution to AD risk still remains elusive. More specifically, it remains unclear whether gen...
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Human Milk Oligosaccharide 2′-Fucosyllactose Reduces Neurodegeneration in Stroke Brain
2′-Fucosyllactose (2’-FL) is a major oligosaccharide in human milk and is present at trace levels in cow milk. 2’-FL reduces inflammation in the gastrointestinal tract. Its action in the central nervous system...
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Open AccessCx3cr1CreERT2-driven Atg7 deletion in adult mice induces intestinal adhesion
Microglia are macrophages resident in the central nervous system. C-X3-C motif chemokine receptor 1 (CX3CR1) is a Gαi-coupled seven-transmembrane protein exclusively expressed in the mononuclear phagocyte system ...
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Open AccessAssociation between increased levels of amyloid-β oligomers in plasma and episodic memory loss in Alzheimer’s disease
The objectives of this study were to investigate whether the plasma levels of oligomeric amyloid-β (OAβ) were affected in Alzheimer’s disease (AD) and to examine the associations (or possible correlations) bet...
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Open AccessCoffee intake and decreased amyloid pathology in human brain
Several epidemiological and preclinical studies supported the protective effect of coffee on Alzheimer’s disease (AD). However, it is still unknown whether coffee is specifically related with reduced brain AD ...
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Pifithrin-Alpha Reduces Methamphetamine Neurotoxicity in Cultured Dopaminergic Neurons
Methamphetamine (Meth) is a widely abused stimulant. High-dose Meth induces degeneration of dopaminergic neurons through p53-mediated apoptosis. A recent study indicated that treatment with the p53 inhibitor, ...
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Open AccessChronic restraint stress induces hippocampal memory deficits by impairing insulin signaling
Chronic stress is a psychologically significant factor that impairs learning and memory in the hippocampus. Insulin signaling is important for the development and cognitive function of the hippocampus. However...
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Open AccessOligomeric forms of amyloid-β protein in plasma as a potential blood-based biomarker for Alzheimer’s disease
Soluble amyloid-β (Aβ) oligomers are the major toxic substances associated with the pathology of Alzheimer’s disease (AD). The ability to measure Aβ oligomer levels in the blood would provide simple and minima...
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Open AccessDynamic changes of oligomeric amyloid β levels in plasma induced by spiked synthetic Aβ42
A reliable blood-based assay is required to properly diagnose and monitor Alzheimer’s disease (AD). Many attempts have been made to develop such a diagnostic tool by measuring amyloid-β oligomers (AβOs) in the...
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Open AccessThe anti-inflammatory role of extranuclear apurinic/apyrimidinic endonuclease 1/redox effector factor-1 in reactive astrocytes
Apurinic/apyrimidinic endonuclease 1 (APE1), a ubiquitous multipurpose protein, is also known as redox effector factor-1 (Ref-1). It is involved in DNA repair and redox signaling and, in turn, oxidative stress...
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Open AccessControl of adult neurogenesis by programmed cell death in the mammalian brain
The presence of neural stem cells (NSCs) and the production of new neurons in the adult brain have received great attention from scientists and the public because of implications to brain plasticity and their ...
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Open AccessAlternatively activated brain-infiltrating macrophages facilitate recovery from collagenase-induced intracerebral hemorrhage
Intracerebral hemorrhage (ICH) is one of the major causes of stroke. After onset of ICH, massive infiltration of macrophages is detected in the peri-hematoma regions. Still, the function of these macrophages i...
