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Article
Cytotoxic constituents from the bark of Salix hulteni
Eight compounds were isolated from the bark of Salix hulteni. Based on spectral data, the isolated compounds were identified as 4-hydroxyacetophenone (1), naringenin (2), aromadendrin (3), catechin (4), picein (5
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Article
Modulation of osteocalcin expression by purmorphamine derivatives
Purmorphamine is a purine analog and it affects osteogenesis, in part, through the modulation of Sonic Hedgehog signaling pathway. However, the underlying mechanism has remained elusive. Previously, we identif...
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Article
Enhanced cytotoxicity of 5-FU by bFGF through up-regulation of uridine phosphorylase 1
Anti cancer agent 5-FU (Fluoro Uracil) is a prodrug that can be metabolized and then activated to interfere with RNA and DNA homeostasis. However, the majority of administered 5-FU is known to be catabolized in v...
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Article
Aldose reductase inhibitors from the leaves of Salix hulteni
From the n-BuOH soluble fraction of the leaves of Salix hulteni, six compounds were isolated as aldose reductase inhibitors. On the basis of spectral data, these compounds were identified as diosmetin-7-O-β-D-glu...
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Article
Development of a new light-weight car audio using polycarbonate/acrylonitrile-butadiene-styrene copolymer composite based hybrid material
Engineering plastics have been applied to automobile components to reduce the weight of an automobile and in essence, improve fuel efficiency. In this study, the application of polycarbonate/acrylonitrile-buta...
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Article
Open AccessThe novel hsa-miR-12528 regulates tumourigenesis and metastasis through hypo-phosphorylation of AKT cascade by targeting IGF-1R in human lung cancer
Lung cancer cases are increasing yearly; however, few novel therapeutic strategies for treating this disease have been developed. Here the dysregulation between microRNAs and oncogenes or tumour-suppressor gen...
