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Article
Open AccessGeneration of double knockout cattle via CRISPR-Cas9 ribonucleoprotein (RNP) electroporation
Genome editing has been considered as powerful tool in agricultural fields. However, genome editing progress in cattle has not been fast as in other mammal species, for some disadvantages including long gestat...
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Article
Curcumin inhibits poly(dA:dT)-induced IL-18 secretion by inhibiting the ASC oligomerization in human keratinocytes
Interleukin (IL)-18, a member of the IL-1 family, has been implicated in the development of a variety of inflammatory skin diseases. The binding of double-stranded (ds) DNA to absent in melanoma (AIM) 2 induce...
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Article
Open AccessHypoxia-induced cancer stemness acquisition is associated with CXCR4 activation by its aberrant promoter demethylation
A hypoxic microenvironment leads to an increase in the invasiveness and the metastatic potential of cancer cells within tumors via the epithelial-mesenchymal transition (EMT) and cancer stemness acquisition. H...
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Article
Open AccessPalmitate induces cisternal ER expansion via the activation of XBP-1/CCTα-mediated phospholipid accumulation in RAW 264.7 cells
Endoplasmic reticulum (ER) stress induces ER expansion. The expansion of the intracisternal space of the ER was found in macrophages associated with human atherosclerotic lesions. We also previously reported t...
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Article
The prediction of dynamic fatigue life of multi-axial loaded system
The purpose of this paper is to compare with estimation of equivalent fatigue load in time domain and frequency domain and estimate the fatigue life of structure with multi-axial vibration loading. The fatigue...
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Article
Structural analysis on the superficial grooving stainless-steel thin-plate rupture discs
A rupture disc is a non-reclosing pressure-relief device actuated by inlet static pressure and designed to function by bursting a pressure-containing disc. It separates fluid from a safety relief valve, and th...
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Article
Palmitate induces COX-2 expression via the sphingolipid pathway-mediated activation of NF-κB, p38, and ERK in human dermal fibroblasts
It has been suggested that free fatty acids (FFA) such as palmitate, which are secreted from enlarged adipocytes in the subcutaneous fat of obese subjects, serve as a link between obesity and altered skin func...
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Article
The adipogenic effect of palmitate in mouse bone marrow-derived mesenchymal stem cells
In the present study, we examined the effect of palmitate on adipocyte differentiation in mouse bone marrow-derived mesenchymal stem cells (MSCs). Obesity is associated with increased adipocyte differentiation...
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Article
A comparison among Neo-Hookean model, Mooney-Rivlin model, and Ogden model for chloroprene rubber
Neo-Hookean model and Mooney-Rivlin model are hyperelastic material models where the strain energy density function is made from invariants of the left Cauchy-Green deformation tensor. Even though Ogden model ...
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Article
A study on the grooving process of a cross-scored rupture disc
High-pressure facilities such as pressure vessels and storage equipment are widely used in all areas of manufacturing. Although many safety regulations have been enacted, mechanical defects and system operator...
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Article
An experimental study and finite element analysis of weatherstrip
Thermoplastic elastomers (TPE) and ethylene-propylene-diene monomers (EPDM) may be used in place of thermoplastic rubbers in extrusion and injection processes because they are eco-friendly and recyclable. One ...
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Article
Sodium nitroprusside induces autophagic cell death in glutathione-depleted osteoblasts
Previous studies reported that high levels of nitric oxide (NO) induce apoptotic cell death in osteoblasts. We examined molecular mechanisms of cytotoxic injury induced by sodium nitroprusside (SNP), a NO dono...
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Article
An experimental study of nonlinear viscoelastic bushing model for axial mode
A bushing is a device used in automotive suspension systems to cushion the force transmitted from the wheel to the frame of the vehicle. A bushing is essentially a hollow cylinder which is bonded to a solid me...
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Article
Missense mutations of the interleukin-12 receptor beta 1(IL12RB1) and interferon-gamma receptor 1 (IFNGR1) genes are not associated with susceptibility to lepromatous leprosy in Korea
Interleukin-12 receptor beta 1 (IL12RB1), interleukin-12 receptor beta 2 (IL12RB2), and interferon gamma receptor 1 (IFNGR1) perform important roles in the host defense against intracellular pathogens such as My...
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Article
Insertion of a retroviral solo long terminal repeat in mdr-3 locus disrupts mRNA splicing in mice
Previously, the abermectin-induced neurotoxicity of subpopulation of CF-1 mice was shown to be caused by the deficiency of mdr-3 P-glycoprotein. Here, we have characterized the molecular nature of the mdr-3 gene...
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Article
Phospholipase C isozymes selectively couple to specific neurotransmitter receptors
A variety of extracellular signals are transduced across the cell membrane by the enzyme phosphoinositide-specific phospholipase C-β (PLC-β) coupled with guanine-nucleotide-binding G proteins1. There are four iso...
