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Open AccessCreatine kinase-(MB) and hepcidin as candidate biomarkers for early diagnosis of pulmonary tuberculosis: a proof-of-concept study in Lambaréné, Gabon
The present study aimed to evaluate the diagnostic utility of creatine kinase-MB (CK-MB), hepcidin (HEPC), phospholipase A2 group IIA (PLa2G2A), and myosin-binding protein C (MYBPC1) for tuberculosis (TB). The...
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Open AccessDevelopment of sustainable research excellence with a global perspective on infectious diseases: Centre de Recherches Médicales de Lambaréné (CERMEL), Gabon
Medical research in sub-Saharan Africa is of high priority for societies to respond adequately to local health needs. Often enough it remains a challenge to build up capacity in infrastructure and human resour...
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Open AccessSurveillance of the major pathogenic arboviruses of public health concern in Gabon, Central Africa: increased risk of West Nile virus and dengue virus infections
Increasing arbovirus infections have been a global burden in recent decades. Many countries have experienced the periodic emergence of arbovirus diseases. However, information on the prevalence of arboviruses ...
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Open AccessMonitoring of efficacy, tolerability and safety of artemether–lumefantrine and artesunate–amodiaquine for the treatment of uncomplicated Plasmodium falciparum malaria in Lambaréné, Gabon: an open-label clinical trial
Malaria remains a major public health problem, affecting mainly low-and middle-income countries. The management of this parasitic disease is challenged by ever increasing drug resistance. This study, investiga...
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Open AccessThe diagnostic accuracy of the hand-held Raman spectrometer for the identification of anti-malarial drugs
There is a need for accurate and field-applicable instruments for the evaluation of the quality of anti-malarial drugs. The aim of this study was to determine the diagnostic accuracy of the NanoRam®, a handheld R...
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Open AccessStreptococcus agalactiae Serotype Distribution and Antimicrobial Susceptibility in Pregnant Women in Gabon, Central Africa
Neonatal invasive disease due to Streptococcus agalactiae is life threatening and preventive strategies suitable for resource limited settings are urgently needed. Protective coverage of vaccine candidates based ...
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Open AccessAssessing the quality of anti-malarial drugs from Gabonese pharmacies using the MiniLab®: a field study
Recent studies alluded to the alarming scale of poor anti-malarial drug quality in malaria-endemic countries, but also illustrated the major geographical gaps in data on anti-malarial drug quality from endemic...
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Open AccessA combined analysis of immunogenicity, antibody kinetics and vaccine efficacy from phase 2 trials of the RTS,S malaria vaccine
The RTS,S malaria vaccine is currently undergoing phase 3 trials. High vaccine-induced antibody titres to the circumsporozoite protein (CSP) antigen have been associated with protection from infection and epis...
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Open AccessPeripheral blood monocyte-to-lymphocyte ratio at study enrollment predicts efficacy of the RTS,S malaria vaccine: analysis of pooled phase II clinical trial data
RTS,S is the most advanced candidate malaria vaccine but it is only partially protective and the causes of inter-individual variation in efficacy are poorly understood. Here, we investigated whether peripheral...
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Open AccessPatterns of biomedical science production in a sub-Saharan research center
Research activities in sub-Saharan Africa may be limited to delegated tasks due to the strong control from Western collaborators, which could lead to scientific production of little value in terms of its impac...
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Open AccessThe use of paediatric artemisinin combinations in sub-Saharan Africa: a snapshot questionnaire survey of health care personnel
Paediatric drug formulations for artemisinin combination therapy (P-ACT) have been developed over the past few years and have been shown to improve the therapeutic management of young children with uncomplicat...
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Efficacy and safety of a new pediatric artesunate-mefloquine drug formulation for the treatment of uncomplicated falciparum malaria in Gabon
Pädiatrische Medikamentenformulierungen sind ein wichtiger Fortschritt in der Therapie von afrikanischen Kindern, die an Malaria tropica erkrankt sind. In dieser klinischen Studie wurde die Wirksamkeit, Sicher...
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Comparison of Immunological Status of African and European Cord Blood Mononuclear Cells
The cellular aspects of the immunologic development of the fetus during pregnancy have been studied mainly in populations living in economically well developed countries, and there is no data concerning variat...
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Increased prevalence of intestinal helminth infection during pregnancy in a Sub-Saharan African community
Physiologische und immunologische Veränderungen während der Schwangerschaft führen zu einer Modifizierung des Risikos verschiedener Infektionserkrankungen. Im Gegensatz zur bekannten Erhöhung der Malaria-Inzid...
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History and perspectives of medical research at the Albert Schweitzer Hospital in Lambaréné, Gabon
Albert Schweitzer gründete 1913 in Lambaréné, Gabun, eines der ersten tropischen Spitäler, das vorrangig der Gesundheitsversorgung der einheimischen Bevölkerung gewidmet war. 1981 wurde am Albert Schweitzer Sp...
