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Article
Open AccessLyme borreliosis and medical wandering: what do patients think about multidisciplinary management? A qualitative study in the context of scientific and social controversy
To answer to patients’ medical wandering, often due to “unexplained symptoms” of “unexplained diseases” and to misinformation, multidisciplinary care centers for suspected Lyme borreliosis (LB), such as the 5 ...
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Article
Open AccessCombined effects of smoking and HIV infection on the occurrence of aging-related manifestations
Both HIV-1 infection and smoking may contribute to the development of ageing-related manifestations affecting the prognosis of people living with HIV, but it is unclear whether HIV and smoking exert their effe...
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Article
Open AccessAcceptance of diagnosis and management satisfaction of patients with “suspected Lyme borreliosis” after 12 months in a multidisciplinary reference center: a prospective cohort study
Because patients with a “suspicion of Lyme borreliosis (LB)” may experience medical wandering and difficult care paths, often due to misinformation, multidisciplinary care centers were started all over Europe ...
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Article
Open AccessStandardization and harmonization of distributed multi-center proteotype analysis supporting precision medicine studies
Cancer has no borders: Generation and analysis of molecular data across multiple centers worldwide is necessary to gain statistically significant clinical insights for the benefit of patients. Here we conceive...
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Article
Open AccessCharacterization of HIV-1 diversity in various compartments at the time of primary infection by ultradeep sequencing
We used next-generation sequencing to evaluate the quantity and genetic diversity of the HIV envelope gene in various compartments in eight patients with acute infection. Plasma (PL) and seminal fluid (SF) were a...
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Article
Primary HIV Infection: Clinical Presentation, Testing, and Treatment
The purpose of this review was to provide current data on clinical presentation, diagnosis, and treatment of primary HIV infection (PHI).
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Chapter and Conference Paper
New proteomics strategies applied to clinical studies
Advances in proteomics have always been tightly linked to the development of mass spectrometry instrumentation. While for over one decade liquid chromatography/mass spectrometry based proteomics has relied on ...
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Article
Mass spectrometry–based detection and quantification of plasma glycoproteins using selective reaction monitoring
Mass spectrometry–based targeted proteomics is a rapidly expanding method for quantifying proteins in complex clinical samples such as plasma. In conjunction with the stable isotope dilution method, selected r...
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Article
Characterization of the Active Bacterial Community Involved in Natural Attenuation Processes in Arsenic-Rich Creek Sediments
Acid mine drainage of the Carnoulès mine (France) is characterized by acid waters containing high concentrations of arsenic and iron. In the first 30 m along the Reigous, a small creek draining the site, more ...
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Article
Enolases: storage compounds in seeds? Evidence from a proteomic comparison of zygotic and somatic embryos of Cyclamen persicum Mill.
Somatic embryogenesis is well established for the economic relevant ornamental crop Cyclamen and thus could supplement the elaborate propagation via seeds. However, the use of somatic embryogenesis for commercial...
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Article
Open AccessInterrupted coding sequences in Mycobacterium smegmatis: authentic mutations or sequencing errors?
In silico analysis has shown that all bacterial genomes contain a low percentage of ORFs with undetected frameshifts and in-frame stop codons. These interrupted coding sequences (ICDSs) may really be present in t...
