Biomaterials Associated Infection
Immunological Aspects and Antimicrobial Strategies
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Article
Open AccessA Niclosamide-releasing hot-melt extruded catheter prevents Staphylococcus aureus experimental biomaterial-associated infection
Biomaterial-associated infections are a major healthcare challenge as they are responsible for high disease burden in critically ill patients. In this study, we have developed drug-eluting antibacterial cathet...
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Chapter
Biomaterial-Associated Infection: Pathogenesis and Prevention
The use of medical devices, such as urinary stents, catheters, artificial heart valves, prosthetic joints and other implants, collectively often referred to as “biomaterials” has increased dramatically over th...
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Protocol
Photochemical Internalization as a New Strategy to Enhance Efficacy of Antimicrobial Agents Against Intracellular Infections
Pathogens such as Staphylococcus aureus are able to survive in many types of host cells including phagocytes such as neutrophils and macrophages, thereby resulting in intracellular infections. Treatment of intrac...
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Article
Open AccessInterlaboratory study for the evaluation of three microtiter plate-based biofilm quantification methods
Microtiter plate methods are commonly used for biofilm assessment. However, results obtained with these methods have often been difficult to reproduce. Hence, it is important to obtain a better understanding o...
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Article
Open AccessA zebrafish high throughput screening system used for Staphylococcus epidermidisinfection marker discovery
Staphylococcus epidermidis bacteria are a major cause of biomaterial-associated infections in modern medicine. Yet there is little known about the host responses against this normally innocent bacterium in the co...
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Book
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Book
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Chapter
Preventive Measures Against Transcutaneous Device Infections
Transcutaneous medical devices are indispensible in medicine. Infection is the most frequently reported complication of indwelling devices and is associated with substantial costs, morbidity, and even mortalit...
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Chapter
Structure–Function Relationships of Antimicrobial Chemokines
The chemokines are a group of small chemotactic cytokines that play an important role in the innate and adaptive immune system. Their main function is related to the recruitment of white blood cells to sites o...
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Chapter
Tissue Colonization in Biomaterial-Associated Infection
Biomedical devices made of biomaterials predispose to infection as they provide surfaces for biofilm formation by microorganisms. Moreover, their presence in host tissue also compromises the local host immune ...
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Article
Cyclic Tritrpticin Analogs with Distinct Biological Activities
Tritrpticin is a Trp-, Arg-, and Pro-rich cathelicidin peptide with promising antimicrobial activity. Cyclic analogs of tritrpticin were designed using two different approaches: circularization of the backbone...
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Article
Isolation and Characterization of Promoter Regions from Streptococcus gordonii CH1
We aimed to identify transcription signal sequences from Streptococcus gordonii strain CH1 by random chromosomal cloning. Five genomic fragments from a Sau3A digest, which constitutively activated transcription ...
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Chapter
Cell-Adherent Glucan Does Not Protect Endocarditis-Causing Viridans Streptococci against Bactericidal Proteins from Human Blood Platelets
Viridans streptococci are the major cause of native valve infective endocarditis. The ability of isolates to produce an extracellular glucan (dextran) polysaccharide (EPS) has been assumed to enhance bacterial...
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Chapter
Selection System for the Isolation of in Vivo Activated Promoters from Endocarditis-Causing Viridans Streptococci
Infective endocarditis (IE) is a serious infection of the heart with a high morbidity and mortality. In the case of native valve endocarditis (NVE), the infection is often associated with cardiac abnormalities...
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Article
Analysis of the major inducers of the Rhizobium nodA promoter from Vicia sativa root exudate and their activity with different nodD genes
Root exudate of Vicia sativa contains 7 inducers for the nodA promoter of Rhizobium leguminosarum biovar viciae. Six of these inducers are flavanones. One inducer was identified as 3,5,7,3′-tetrahydroxy-4′-methox...
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Chapter and Conference Paper
Flavonoid Compounds as Molecular Signals in Rhizobium — Legume Symbiosis
The bacterium Rhizobium nodulates leguminous and some non -leguminous plants and establishes a symbiotic relationship with its host plant in which the bacterium fixes nitrogen, after differentiation to bacteroids...
