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  1. No Access

    Article

    Fracture-related infection

    Musculoskeletal trauma leading to broken and damaged bones and soft tissues can be a life-threating event. Modern orthopaedic trauma surgery, combined with innovation in medical devices, allows many severe inj...

    T. Fintan Moriarty, Willem-Jan Metsemakers in Nature Reviews Disease Primers (2022)

  2. Article

    Skeletal infections: microbial pathogenesis, immunity and clinical management

    Osteomyelitis remains one of the greatest risks in orthopaedic surgery. Although many organisms are linked to skeletal infections, Staphylococcus aureus remains the most prevalent and devastating causative pathog...

    Elysia A. Masters, Benjamin F. Ricciardi in Nature Reviews Microbiology (2022)

  3. No Access

    Article

    An Exopolysaccharide Produced by Bifidobacterium longum 35624® Inhibits Osteoclast Formation via a TLR2-Dependent Mechanism

    The probiotic Bifidobacterium longum subsp. longum 35624® (B. longum 35624®), with its surface exopolysaccharide (EPS624), has previously been demonstrated to induce immunoregulatory responses in the host and may...

    Alexandra Wallimann, Maria Hildebrand, David Groeger in Calcified Tissue International (2021)

  4. Article

    Open Access

    Longitudinal time-lapse in vivo micro-CT reveals differential patterns of peri-implant bone changes after subclinical bacterial infection in a rat model

    Subclinical infection associated with orthopedic devices can be challenging to diagnose. The goal of this study was to evaluate longitudinal, microcomputed tomography (microCT) imaging in a rat model of subcli...

    Vincent A. Stadelmann, Keith Thompson, Stephan Zeiter in Scientific Reports (2020)

  5. No Access

    Chapter

    Periprosthetic Joint Infection

    Total joint arthroplasty (TJA), the implantation of an artificial joint replacement, has become a relatively commonly practiced operation in many parts of the world. The most common reasons for performing a TJ...

    Aron Keshishian, Andrew Foster, Georg Matziolis in Racing for the Surface (2020)

  6. No Access

    Chapter

    Complications in Orthopedic Trauma Surgery: Fracture-Related Infection

    Fracture-related infection (FRI), in particular when associated with internal fixation hardware, is one of the most dreaded complications in orthopedic trauma surgery. Often hard to diagnose, these infections ...

    Marc Antoine Burch, T. Fintan Moriarty, Richard Kuehl in Racing for the Surface (2020)

  7. No Access

    Article

    Prevalence and quantification of contamination of knitted cotton outer gloves during hip and knee arthroplasty surgery

    Knitted cotton outer gloves offer protection against surgical glove perforation and provide improved grip on instruments. These gloves absorb blood and other fluids during surgery, and may therefore also accum...

    Thorsten Wichmann, T. Fintan Moriarty in Archives of Orthopaedic and Trauma Surgery (2019)

  8. Article

    Open Access

    Disease-associated genotypes of the commensal skin bacterium Staphylococcus epidermidis

    Some of the most common infectious diseases are caused by bacteria that naturally colonise humans asymptomatically. Combating these opportunistic pathogens requires an understanding of the traits that differen...

    Guillaume Méric, Leonardos Mageiros, Johan Pensar, Maisem Laabei in Nature Communications (2018)

  9. No Access

    Book

    Biomaterials Associated Infection

    Immunological Aspects and Antimicrobial Strategies

    T. Fintan Moriarty, Sebastian A.J. Zaat (2013)

  10. No Access

    Chapter

    Animal Models of Orthopedic Implant-Related Infection

    Musculoskeletal infection remains a great challenge in orthopedic and trauma surgery. Despite best medical and surgical practice and significant advances in research and development, bone and implant associate...

    Lorenzo Calabro, Cameron Lutton in Biomaterials Associated Infection (2013)

  11. No Access

    Chapter

    Infection in Fracture Fixation: Device Design and Antibiotic Coatings Reduce Infection Rates

    Musculoskeletal infection is one of the most common complications associated with surgical fixation of bones fractured during trauma. Severe fractures with extensive tissue damage are particularly prone to inf...

    Gerhard Schmidmaier, Abhay D. Gahukamble in Biomaterials Associated Infection (2013)

  12. No Access

    Article

    Infection in fracture fixation: Can we influence infection rates through implant design?

    Musculoskeletal infection is one of the most common complications associated with surgical fixation of bones fractured during trauma. These infections usually involve bacterial colonisation and biofilm formati...

    T. Fintan Moriarty, U. Schlegel, S. Perren in Journal of Materials Science: Materials in… (2010)