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  1. No Access

    Article

    Metabolic shift induced by systemic activation of T cells in PD-1-deficient mice perturbs brain monoamines and emotional behavior

    Fagarasan and colleagues show that excessive activation of T cells in mice deficient in the inhibitory receptor PD-1 causes a systemic decrease in tryptophan and tyrosine, which leads to deficiency in serotoni...

    Michio Miyajima, Baihao Zhang, Yuki Sugiura, Kazuhiro Sonomura… in Nature Immunology (2017)

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    Article

    Loss of neuronal 3D chromatin organization causes transcriptional and behavioural deficits related to serotonergic dysfunction

    The interior of the neuronal cell nucleus is a highly organized three-dimensional (3D) structure where regions of the genome that are linearly millions of bases apart establish sub-structures with specialized ...

    Satomi Ito, Adriana Magalska, Manuel Alcaraz-Iborra… in Nature Communications (2014)

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    Article

    Pretransplant serum ferritin is associated with bloodstream infections within 100 days of allogeneic stem cell transplantation for myeloid malignancies

    We retrospectively studied the association between iron overload and bloodstream infections (BSI) in the 100-day period following allogeneic hematopoietic stem cell transplantation (allo-HSCT) for acute myeloi...

    Takayoshi Tachibana, Masatsugu Tanaka… in International Journal of Hematology (2011)

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    Article

    Cerebral venous sinus thrombosis after allogeneic stem cell transplantation

    Kenji Motohashi, Maki Hagihara, Satomi Ito… in International Journal of Hematology (2010)

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    Article

    The presence of mature granulocytes/monocytes derived from leukemic cells in MLL-associated leukemia

    We observed the mature granulocytes/monocytes derived from leukemic cells in patients with acute myeloid leukemia who present mixed lineage leukemia gene (MLL). Morphologic observation and fluorescence in situ...

    Shoichi Kobayashi, Masato Obata, Maki Hagihara… in International Journal of Hematology (2009)

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    Article

    Separate domains of AID are required for somatic hypermutation and class-switch recombination

    Activation-induced cytidine deaminase (AID) is essential for class-switch recombination (CSR) and somatic hypermutation (SHM). Mutants with changes in the C-terminal region of AID retain SHM but lose CSR activ...

    Reiko Shinkura, Satomi Ito, Nasim A Begum, Hitoshi Nagaoka… in Nature Immunology (2004)

  7. No Access

    Article

    AID mutant analyses indicate requirement for class-switch-specific cofactors

    Activation-induced cytidine deaminase (AID) is the essential and sole B cell–specific factor required for class-switch recombination (CSR) and somatic hypermutation (SHM). However, it is not known how AID diff...

    Van-Thanh Ta, Hitoshi Nagaoka, Nadia Catalan, Anne Durandy… in Nature Immunology (2003)

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    Article

    Th1/Th2 cytokine profiles and their relationship to clinical features in patients with chronic hepatitis C virus infection

    An imbalance in helper T-cell type 1 (Th1) and type 2 (Th2) cytokines is suggested to play an important role in the pathogenesis of chronic viral infections, but this issue is not resolved in patients with he...

    Satoshi Sobue, Tomoyuki Nomura, Tetsuya Ishikawa, Satomi Ito… in Journal of Gastroenterology (2001)

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    Article

    Microscopic observations on tissue calcium distribution in the brown alga,Undaria pinnatifida (Harvey) Suringar

    The distribution of Ca2+ in thallus tissues of the brown algaUndaria pinnatifida was investigated by microspectro-photometric analysis after fixation with Carnoy's reagent and staining with an alizarine sulfonate...

    Satomi Ito, Tamotsu Miyoshi in Journal of Applied Phycology (1993)