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Article
Open AccessPartSeg: a tool for quantitative feature extraction from 3D microscopy images for dummies
Bioimaging techniques offer a robust tool for studying molecular pathways and morphological phenotypes of cell populations subjected to various conditions. As modern high-resolution 3D microscopy provides acce...
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Article
Open AccessUltrastructural visualization of 3D chromatin folding using volume electron microscopy and DNA in situ hybridization
The human genome is extensively folded into 3-dimensional organization. However, the detailed 3D chromatin folding structures have not been fully visualized due to the lack of robust and ultra-resolution imagi...
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Article
Localization and regulation of PML bodies in the adult mouse brain
PML is a tumor suppressor protein involved in the pathogenesis of promyelocytic leukemia. In non-neuronal cells, PML is a principal component of characteristic nuclear bodies. In the brain, PML has been implic...
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Article
Loss of neuronal 3D chromatin organization causes transcriptional and behavioural deficits related to serotonergic dysfunction
The interior of the neuronal cell nucleus is a highly organized three-dimensional (3D) structure where regions of the genome that are linearly millions of bases apart establish sub-structures with specialized ...
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Article
P-glycoprotein expression does not change the apoptotic pathway induced by curcumin in HL-60 cells
One of the mechanisms responsible for the multidrug resistance (MDR) phenotype of cancer cells is overexpression of so-called ATP-dependent drug efflux proteins: the 170-kDa P-glycoprotein (P-gp) encoded by the M...
