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Article
Open AccessDifferential methylation analysis in neuropathologically confirmed dementia with Lewy bodies
Dementia with Lewy bodies (DLB) is a common form of dementia in the elderly population. We performed genome-wide DNA methylation map** of cerebellar tissue from pathologically confirmed DLB cases and control...
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Article
Open AccessCombined epigenetic/genetic study identified an ALS age of onset modifier
Age at onset of amyotrophic lateral sclerosis (ALS) is highly variable (eg, 27–74 years in carriers of the G4C2-expansion in C9orf72). It might be influenced by environmental and genetic factors via the modulatio...
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Article
Genome sequencing analysis identifies new loci associated with Lewy body dementia and provides insights into its genetic architecture
The genetic basis of Lewy body dementia (LBD) is not well understood. Here, we performed whole-genome sequencing in large cohorts of LBD cases and neurologically healthy controls to study the genetic architect...
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Article
Author Correction: Cellular senescence and Alzheimer disease: the egg and the chicken scenario
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Cellular senescence and Alzheimer disease: the egg and the chicken scenario
Globally, 50 million people live with dementia, with Alzheimer disease (AD) being responsible for two-thirds of the total cases. As ageing is the main risk factor for dementia-related neurodegeneration, change...
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Article
Open AccessALDH1A1 regulates postsynaptic μ–opioid receptor expression in dorsal striatal projection neurons and mitigates dyskinesia through transsynaptic retinoic acid signaling
Aldehyde dehydrogenase 1A1 (ALDH1A1), a retinoic acid (RA) synthase, is selectively expressed by the nigrostriatal dopaminergic (nDA) neurons that preferentially degenerate in Parkinson’s disease (PD). ALDH1A1...
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Article
Rotenone Induces the Formation of 4-Hydroxynonenal Aggresomes. Role of ROS-Mediated Tubulin Hyperacetylation and Autophagic Flux Disruption
Oxidative stress causes cellular damage by (i) altering protein stability, (ii) impairing organelle function, or (iii) triggering the formation of 4-HNE protein aggregates. The catabolic process known as autop...
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Chapter
Autophagy as a Neuroprotective Mechanism Against 3-Nitropropionic Acid-Induced Cell Death
The natural environmental toxin 3-Nitropropionic acid (3-NP) is used to induce situations somehow similar to those that take place in human patients suffering the progressive neurodegenerative illness known as...
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Reference Work Entry In depth
6-Hydroxydopamine as Preclinical Model of Parkinson’s Disease
Like many other diseases, Parkinson’s disease (PD) requires preclinical models to understand the underlying molecular and cellular mechanisms that cause the disorder. Such models will also help to identify nov...
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Reference Work Entry In depth
Pharmacology and Pathology of Superoxide Dismutases (SOD)
Organisms harbor a variety of molecules and enzymes which are members of a vast array of antioxidating networks in maintaining their physiological redox balance. Superoxide dismutase (SOD) family members are e...
