11 Result(s)
within
Sara A. Grimm
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessCD11b+ lung dendritic cells at different stages of maturation induce Th17 or Th2 differentiation
Dendritic cells (DC) in the lung that induce Th17 differentiation remain incompletely understood, in part because conventional CD11b+ DCs (cDC2) are heterogeneous. Here, we report a population of cDCs that rapidl...
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Open AccessGLIS1 regulates trabecular meshwork function and intraocular pressure and is associated with glaucoma in humans
Chronically elevated intraocular pressure (IOP) is the major risk factor of primary open-angle glaucoma, a leading cause of blindness. Dysfunction of the trabecular meshwork (TM), which controls the outflow of...
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Article
Open AccessDNMT1 reads heterochromatic H4K20me3 to reinforce LINE-1 DNA methylation
DNA methylation and trimethylated histone H4 Lysine 20 (H4K20me3) constitute two important heterochromatin-enriched marks that frequently cooperate in silencing repetitive elements of the mammalian genome. How...
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Open AccessInteraction of the pioneer transcription factor GATA3 with nucleosomes
During cellular reprogramming, the pioneer transcription factor GATA3 binds chromatin, and in a context-dependent manner directs local chromatin remodeling and enhancer formation. Here, we use high-resolution ...
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Open AccessComprehensive structure-function characterization of DNMT3B and DNMT3A reveals distinctive de novo DNA methylation mechanisms
Mammalian DNA methylation patterns are established by two de novo DNA methyltransferases, DNMT3A and DNMT3B, which exhibit both redundant and distinctive methylation activities. However, the related molecular ...
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Article
Open AccessAlterations in promoter interaction landscape and transcriptional network underlying metabolic adaptation to diet
Metabolic adaptation to nutritional state requires alterations in gene expression in key tissues. Here, we investigated chromatin interaction dynamics, as well as alterations in cis-regulatory loci and transcr...
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Article
Open AccessRUNX1 maintains the identity of the fetal ovary through an interplay with FOXL2
Sex determination of the gonads begins with fate specification of gonadal supporting cells into either ovarian pre-granulosa cells or testicular Sertoli cells. This fate specification hinges on a balance of tr...
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Article
Open AccessDNA methylation in mice is influenced by genetics as well as sex and life experience
DNA methylation is an essential epigenetic process in mammals, intimately involved in gene regulation. Here we address the extent to which genetics, sex, and pregnancy influence genomic DNA methylation by inte...
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Open AccessDosage compensation and DNA methylation landscape of the X chromosome in mouse liver
DNA methylation plays a key role in X-chromosome inactivation (XCI), a process that achieves dosage compensation for X-encoded gene products between mammalian female and male cells. However, differential sex c...
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Article
Open AccessLoss of Glis3 causes dysregulation of retrotransposon silencing and germ cell demise in fetal mouse testis
Fetal germ cell development is regulated by an elaborate combination of cell-extrinsic and cell-intrinsic signals. Here we identify a novel role for the Krüppel-like transcription factor Gli-Similar 3 (Glis3) in ...
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Article
Open AccessGATA3 zinc finger 2 mutations reprogram the breast cancer transcriptional network
GATA3 is frequently mutated in breast cancer; these mutations are widely presumed to be loss-of function despite a dearth of information regarding their effect on disease course or their mechanistic impact on ...
