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Article
Open AccessInteraction of the pioneer transcription factor GATA3 with nucleosomes
During cellular reprogramming, the pioneer transcription factor GATA3 binds chromatin, and in a context-dependent manner directs local chromatin remodeling and enhancer formation. Here, we use high-resolution ...
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Article
Open AccessAuthor Correction: CHD3 helicase domain mutations cause a neurodevelopmental syndrome with macrocephaly and impaired speech and language
The HTML and PDF versions of this Article were updated after publication to remove images of one individual from Figure 1.
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Article
Open AccessAuthor Correction: CHD3 helicase domain mutations cause a neurodevelopmental syndrome with macrocephaly and impaired speech and language
The original version of this Article contained an error in the spelling of the author Laurence Faivre, which was incorrectly given as Laurence Faive. This has now been corrected in both the PDF and HTML versio...
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Article
Open AccessDNA methylation in mice is influenced by genetics as well as sex and life experience
DNA methylation is an essential epigenetic process in mammals, intimately involved in gene regulation. Here we address the extent to which genetics, sex, and pregnancy influence genomic DNA methylation by inte...
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Article
Open AccessCHD3 helicase domain mutations cause a neurodevelopmental syndrome with macrocephaly and impaired speech and language
Chromatin remodeling is of crucial importance during brain development. Pathogenic alterations of several chromatin remodeling ATPases have been implicated in neurodevelopmental disorders. We describe an index...
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Article
Open AccessGATA3 zinc finger 2 mutations reprogram the breast cancer transcriptional network
GATA3 is frequently mutated in breast cancer; these mutations are widely presumed to be loss-of function despite a dearth of information regarding their effect on disease course or their mechanistic impact on ...
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Article
Reversing SKI–SMAD4-mediated suppression is essential for TH17 cell differentiation
TGFβ signalling regulates T helper 17 (TH17) cell differentiation by reversing SKI–SMAD4-mediated suppression of RORγt, revealing a potential therapeutic target for treating TH17-related diseases.
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Article
Open AccessChromatin architecture may dictate the target site for DMC1, but not for RAD51, during homologous pairing
In eukaryotes, genomic DNA is compacted as chromatin, in which histones and DNA form the nucleosome as the basic unit. DMC1 and RAD51 are essential eukaryotic recombinases that mediate homologous chromosome pa...
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Article
Open AccessGATA3-dependent cellular reprogramming requires activation-domain dependent recruitment of a chromatin remodeler
Transcription factor-dependent cellular reprogramming is integral to normal development and is central to production of induced pluripotent stem cells. This process typically requires pioneer transcription fac...
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Article
Open AccessNap1 stimulates homologous recombination by RAD51 and RAD54 in higher-ordered chromatin containing histone H1
Homologous recombination plays essential roles in mitotic DNA double strand break (DSB) repair and meiotic genetic recombination. In eukaryotes, RAD51 promotes the central homologous-pairing step during homolo...
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Article
Open AccessBreast tumor specific mutation in GATA3 affects physiological mechanisms regulating transcription factor turnover
The transcription factor GATA3 is a favorable prognostic indicator in estrogen receptor-α (ERα)-positive breast tumors in which it participates with ERα and FOXA1 in a complex transcriptional regulatory progra...
