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Article
Open AccessDNMT1 reads heterochromatic H4K20me3 to reinforce LINE-1 DNA methylation
DNA methylation and trimethylated histone H4 Lysine 20 (H4K20me3) constitute two important heterochromatin-enriched marks that frequently cooperate in silencing repetitive elements of the mammalian genome. How...
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Article
UVR8 interacts with de novo DNA methyltransferase and suppresses DNA methylation in Arabidopsis
DNA methylation is an important epigenetic gene regulatory mechanism conserved in eukaryotes. Emerging evidence shows DNA methylation alterations in response to environmental cues. However, the mechanism of ho...
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Article
YY1 interacts with guanine quadruplexes to regulate DNA loo** and gene expression
The DNA guanine quadruplexes (G4) play important roles in multiple cellular processes, including DNA replication, transcription and maintenance of genome stability. Here, we showed that Yin and Yang 1 (YY1) ca...
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Article
Different effects of canopy and understory nitrogen addition on soil organic carbon and its related processes in a subtropical forest
The response of forest soil organic carbon (SOC) to atmospheric nitrogen (N) deposition is generally studied via understory N addition, whereas canopy processes are often ignored. This implies potential bias i...
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Article
Structural basis for STAT2 suppression by flavivirus NS5
Suppressing cellular signal transducers of transcription 2 (STAT2) is a common strategy that viruses use to establish infections, yet the detailed mechanism remains elusive, owing to a lack of structural infor...
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Article
Open AccessComprehensive structure-function characterization of DNMT3B and DNMT3A reveals distinctive de novo DNA methylation mechanisms
Mammalian DNA methylation patterns are established by two de novo DNA methyltransferases, DNMT3A and DNMT3B, which exhibit both redundant and distinctive methylation activities. However, the related molecular ...
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Article
Open AccessStructure and regulation of ZCCHC4 in m6A-methylation of 28S rRNA
N6-methyladenosine (m6A) modification provides an important epitranscriptomic mechanism that critically regulates RNA metabolism and function. However, how m6A writers attain substrate specificities remains uncle...
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Article
pH Induces Thermal Unfolding of UTI: An Implication of Reversible and Irreversible Mechanism Based on the Analysis of Thermal Stability, Thermodynamic, Conformational Characterization
The thermal unfolding of Urinary Trypsin Inhibitor (UTI) was studied by several methods: Circular Dichroism (CD), Fluorescence and UV–Vis spectra. Thermal melting of UTI, dissolved in the neutral and basic buf...
