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Article
Open AccessComparison of diagnosis-based risk adjustment methods for episode-based costs to apply in efficiency measurement
The recent rising health spending intrigued efficiency and cost-based performance measures. However, mortality risk adjustment methods are still under consideration in cost estimation, though methods specific ...
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Article
Open AccessCircadian phase advances in children during cam** life according to the natural light-dark cycle
It is known that the circadian rhythm phase in adults can be advanced in a natural light-dark cycle without electrical lighting. However, the effect of advanced sleep-wake timing according to the natural light...
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Article
Open AccessIntake of l-serine before bedtime prevents the delay of the circadian phase in real life
It has been shown in laboratory experiments using human subjects that ingestion of the non-essential amino acid l-serine before bedtime enhances the advance of circadian phase induced by light exposure the next m...
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Article
Open AccessSerum IGF-1 in patients with rheumatoid arthritis: correlation with disease activity
Insulin-like growth factor (IGF)-1 participates in modulating immunity and inflammation. Its bioactivity is controlled by six IGF-binding proteins (IGFBP-1 to IGFBP-6). In particular, the IGFBP-3 level is repo...
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Article
Open AccessEarly experience of laparoscopic resection and comparison with open surgery for gastric gastrointestinal stromal tumor: a multicenter retrospective study
The advantages of laparoscopic resection over open surgery in the treatment of gastric gastrointestinal stromal tumor (GIST) are not conclusive. This study aimed to evaluate the postoperative and oncologic out...
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Article
Open AccessDiurnal variations of brown fat thermogenesis and fat oxidation in humans
Disturbed circadian rhythm is associated with an increased risk of obesity and metabolic disorders. Brown adipose tissue (BAT) is a site of nonshivering thermogenesis (NST) and plays a role in regulating whole...
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Article
Open AccessChronic inflammation-induced senescence impairs immunomodulatory properties of synovial fluid mesenchymal stem cells in rheumatoid arthritis
Although the immunomodulatory properties of mesenchymal stem cells (MSCs) have been highlighted as a new therapy for autoimmune diseases, including rheumatoid arthritis (RA), the disease-specific characteristi...
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Article
Appropriate Number of Adjuvant Chemotherapy Cycles for Patients with Stage 2 or 3 Gastric Cancer After Curative Gastrectomy: A Multicenter Cohort Study
Few studies have presented evidence pertaining to the adequate minimum number of adjuvant chemotherapy (AC) cycles required to achieve an oncologic benefit for gastric cancer.
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Article
Open AccessIs the use of high correlated color temperature light at night related to delay of sleep timing in university students? A cross-country study in Japan and China
Blue-enriched white light at night has the potential to delay the circadian rhythm in daily life. This study was conducted to determine whether the use of high correlated color temperature (CCT) light at home ...
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Article
The Effects of Climate Change on the Reuse of Agricultural Drainage Water in Irrigation
Climate change is projected to have a major impact on agricultural water resources availability. Comprehending the effects of climate change on water supplies for agriculture is an essential aid for the effect...
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Article
Open AccessThe regional diversity of gut microbiome along the GI tract of male C57BL/6 mice
The proliferation and survival of microbial organisms including intestinal microbes are determined by their surrounding environments. Contrary to popular myth, the nutritional and chemical compositions, water ...
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Article
Open AccessBlockade of translationally controlled tumor protein attenuated the aggressiveness of fibroblast-like synoviocytes and ameliorated collagen-induced arthritis
Histamine releasing factor/translationally controlled tumor protein (HRF/TCTP) stimulates cancer progression and allergic responses, but the role of HRF/TCTP in rheumatoid arthritis (RA) remains undefined. In ...
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Article
Threshold-based portfolio: the role of the threshold and its applications
This paper aims at develo** a new method by which to build a data-driven portfolio featuring a target risk–return. We first present a comparative study of recurrent neural network models (RNNs), including a ...
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Article
Multimodal deep learning for finance: integrating and forecasting international stock markets
In today’s increasingly international economy, return and volatility spillover effects across international equity markets are major macroeconomic drivers of stock dynamics. Thus, information regarding foreign...
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Article
Long-term durability of offshore wind turbine composite blades based on nonlinear load behavior due to pitch movement
This study proposes a fatigue life prediction method for offshore wind turbines consisting of a fatigue load calculation method that accounts for external environmental factors and system interaction, as well ...
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Article
Open AccessIdentification of a molecular signature of prognostic subtypes in diffuse-type gastric cancer
Although recent advances in high-throughput technology have provided many insights into gastric cancer (GC), few reliable biomarkers for diffuse-type GC have been identified. Here, we aim to identify a prognos...
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Article
A Review: Mechanical and Interfacial Properties of Composites after Diverse Types of Aging Using Micromechanical Evaluation
Composites has been an area of active research for the past several decades due to their lightweight and good mechanical properties. However, the aging of fiber reinforced composites is a major issue due to ex...
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Article
Open AccessLong-term efficacy, safety and immunogenicity in patients with rheumatoid arthritis continuing on an etanercept biosimilar (LBEC0101) or switching from reference etanercept to LBEC0101: an open-label extension of a phase III multicentre, randomised, double-blind, parallel-group study
To evaluate the long-term efficacy, safety and immunogenicity of continuing LBEC0101; the etanercept (ETN) biosimilar; or switching from the ETN reference product (RP) to LBEC0101 in patients with rheumatoid a...
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Article
Open AccessWhole genome MBD-seq and RRBS analyses reveal that hypermethylation of gastrointestinal hormone receptors is associated with gastric carcinogenesis
DNA methylation is a regulatory mechanism in epigenetics that is frequently altered during human carcinogenesis. To detect critical methylation events associated with gastric cancer (GC), we compared three DNA...
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Article
Effects of SO2 contamination on rising CO2 drops under high pressure
Although the flow dynamics of pure liquid drops in other liquids has been well researched, little attention has been paid to the impacts of impurities. Hence, most of research is not directly applicable to the...
