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Article
Open AccessActivation of TCA cycle restrains virus-metabolic hijacking and viral replication in mouse hepatitis virus-infected cells
One of coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has caused coronavirus disease 2019 (COVID-19) pandemic and threatened worldwide. However, therapy for COVID-19 has rarely been...
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Article
Open AccessProgesterone receptor membrane component 1 reduces cardiac steatosis and lipotoxicity via activation of fatty acid oxidation and mitochondrial respiration
Obesity is implicated in cardiovascular disease and heart failure. When fatty acids are transported to and not adequately oxidized in cardiac cells, they accumulate, causing lipotoxicity in the heart. Since he...
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Article
Open AccessAbsence of progesterone receptor membrane component 1 reduces migration and metastasis of breast cancer
Progesterone receptor membrane component 1 (Pgrmc1) is a non-classical progesterone receptor associated with the development of the mammary gland and xenograft-induced breast cancer. Importantly, Pgrmc1 is ass...
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Article
Open AccessProgesterone increases blood glucose via hepatic progesterone receptor membrane component 1 under limited or impaired action of insulin
Hepatic gluconeogenesis is the main pathway for blood glucose maintenance activated during fasting. Retardation of insulin action, such as in diabetes mellitus, activates gluconeogenesis during the fed state. ...
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Article
Open AccessDietary intake of genistein suppresses hepatocellular carcinoma through AMPK-mediated apoptosis and anti-inflammation
Women have a lower risk of hepatocellular carcinoma (HCC) than men, and the decreased possibility of HCC in women is thought to depend on estrogen levels. As a soybean-isoflavone product, genistein has estroge...
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Article
Open AccessLoss of progesterone receptor membrane component 1 promotes hepatic steatosis via the induced de novo lipogenesis
Non-alcoholic fatty liver disease (NAFLD) results from triglyceride accumulation within the liver and some of them advances to non-alcoholic steatohepatitis (NASH). It is important to note that in NAFLD develo...
