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Article
Open AccessLong-term exposure to house dust mites accelerates lung cancer development in mice
Individuals with certain chronic inflammatory lung diseases have a higher risk of develo** lung cancer (LC). However, the underlying mechanisms remain largely unknown. Here, we hypothesized that chronic expo...
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Article
Open AccessNeuronal TRPV1 activation regulates alveolar bone resorption by suppressing osteoclastogenesis via CGRP
The transient receptor potential vanilloid 1 (TRPV1) channel is abundantly expressed in peripheral sensory neurons where it acts as an important polymodal cellular sensor for heat, acidic pH, capsaicin and oth...
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Article
Open AccessERK5 signalling rescues intestinal epithelial turnover and tumour cell proliferation upon ERK1/2 abrogation
The ERK1/2 MAPK signalling module integrates extracellular cues that induce proliferation and differentiation of epithelial lineages, and is an established oncogenic driver, particularly in the intestine. Howe...
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Article
Transient Receptor Potential (TRP) channels in T cells
The transient receptor potential (TRP) family of ion channels is widely expressed in many cell types and plays various physiological roles. Growing evidence suggests that certain TRP channels are functionally ...
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Article
The ion channel TRPV1 regulates the activation and proinflammatory properties of CD4+ T cells
The membrane channel TRPV1 is well studied as a pain receptor, but its function beyond sensory neurons remains unclear. Raz and colleagues demonstrate that TRPV1 is also a non–store-operated calcium channel on...
