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Chapter
Dose Studies for Human Growth Hormone in Hypopituitarism
A number of studies have reported growth responses to different doses of human growth hormone (hGH). Most such reports deal with the first year or first 18 months of therapy in hypopituitarism. Twice-a-week (b...
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Chapter
Growth-Stimulating Effects of Human Growth Hormone Therapy in Turner’s Syndrome
Prior to 1982 and during the first 25 years of its clinical availability, the use of human growth hormone (hGH) for the treatment of Turner’s syndrome was very limited because of inadequate supplies. A review ...
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Chapter
Short Normal Children in Therapeutic Trial of Human Growth Hormone Responsiveness
This project was designed to evaluate the effectiveness of human growth hormone (hGH) in children with short stature who are growing at subnormal rates. Although it has previously been believed that such patie...
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Chapter
The National Hormone and Pituitary Program
Following the discovery of human growth hormone (hGH) in 1956 and proof of its effectiveness as a therapeutic agent for hypopituitarism in 1958, there developed an urgent need to obtain human pituitary glands ...
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Article
22 GROWTH IMPAIRMENT ASSOCIATED WITH HYPERCORTISOLISM: RESPONSE TO GROWTH HORMONE THERAPY
Hypercortisolism decreases responsiveness to GH, leading to impairment of growth. The 24-h integrated concentration of cortisol (IC-F) proved to be an accurate diagnostic procedure for hypercortisolism. In chi...
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Article
THE RATIO OF GROWTH HORMONE (GH) BY TANDEM MONOCLONAL ASSAY/POLYCLONAL RIA DOES NOT PREDICT RESPONSE TO GH THERAPY
Blethen and Chaslow (JCEM 57:1031, 1983), recently reported that the ratio of GH by Tandem Hybritech monoclonal immunoradiometric assay (Tandem) to standard polyclonal radioimmunoassay (RIA), might predict the...
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Article
RESPONSE TO THERAPY IN CHILDREN WITH LOW INTEGRATED CONCENTRATION OF GROWTH HORMONE
We have previously demonstrated that the response of GH to pharmacologic stimulation does not always correspond to the actual integrated concentration of GH (ICGH)(JCEM 48:811, 1979). Spiliotis et al have repo...
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Article
Excessive Follicle-stimulating Hormone Excretion and Production in Males with Untreated Congenital Adrenal Hyperplasia
Summary: The 24-hr urinary excretions of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) were measured in seven males with untreated congenital adrenal hyperplasia. The patients aged 1–10 years...
