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Article
Abstracts from the symposium on recent advances in Paget’s disease of bone and related bone diseases
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Article
EFFECT OF LONGTERM GnRH AGONISTS (CnRHa) ON FINAL HEIGHT IN CHILDREN WITH TRUE PRECOCIOUS PUBERTY (TPP)
We have compared the final height of GnRHa treated patients to untreated patients with TPP, 45 children received deslorelin (4-8 ug/kg/d s.c.) or nafarelin acetate (800ug IN bid). 26 of the 45 (20F/6M) are at ...
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Article
N-METHYL-D-ASPARTATE (NMDA) STIMULATES LHRH RELEASE VIA THE NMDA RECEPTOR IN AN LHRH NEURONAL CELL LINE (GT1-1)
Previous studies demonstrated that an excitatory amino acid analog, NMDA, stimulates LHRH secretion in the ovine fetus, prepubertal primate and rat at the hypothalamic level. It is not known if this stimulator...
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Chapter
Dose Studies for Human Growth Hormone in Hypopituitarism
A number of studies have reported growth responses to different doses of human growth hormone (hGH). Most such reports deal with the first year or first 18 months of therapy in hypopituitarism. Twice-a-week (b...
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Chapter
Growth-Stimulating Effects of Human Growth Hormone Therapy in Turner’s Syndrome
Prior to 1982 and during the first 25 years of its clinical availability, the use of human growth hormone (hGH) for the treatment of Turner’s syndrome was very limited because of inadequate supplies. A review ...
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Chapter
Short Normal Children in Therapeutic Trial of Human Growth Hormone Responsiveness
This project was designed to evaluate the effectiveness of human growth hormone (hGH) in children with short stature who are growing at subnormal rates. Although it has previously been believed that such patie...
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Chapter
Somatomedin C in the Ovine Fetus and Neonate
The chronically catheterized sheep model offers a useful approach to the study of fetal and neonatal neuroendocrine and pituitary maturation.(1) The ontogeny of somatomedin (SM) concentrations in the normal ovine...
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Chapter
Clinical Studies with Recombinant-DNA-Derived Methionyl-Human Growth Hormone in Growth Hormone-Deficient Children
The advent of recombinant-DNA technology provides the prospect of synthesis of human growth hormone (hGH) in unlimited quantitites. Since 1% of protein synthesized by Escherichia coli by this procedure is hGH, th...
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Chapter
Turner’s Syndrome and Human Growth Hormone
The mechanism responsible for short stature in patients with Turner’s syndrome is unknown. Growth retardation in the syndrome of gonadal dysgenesis is often present in utero; growth velocity after infancy and ear...
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Article
CRYPTOSPORIDIOSIS IN CHILDREN
Of 553 stool specimens from children under 18 years of age screened by a merthiolate-iodineformalin technique at the Houston City Health Department from July to November, 1983, 5(0.9%) contained cryptosporidia...
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Article
VARIABLE SUPPRESSION OF IN VITRO GRANULOPOIESIS BY β-LACTAM ANTIBIOTICS
The effects of a number of β-lactam antibiotics (βL-A) on in vitro granulocyte/macrophage colony formation (CFUGM) in the agar culture system were studied. Normal bone marrow mononuclear cells (BM-MNC) (2 × 105/m...
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Article
Treatment of Cushing's disease (C.D.) by transphenoidal microadenectomy (Tr.M.) in childhood and adolescence
The efficacy of Tr.M. in the treatment of C.D. in children and adolescents has not been assessed. We treated 8 patients (7-6/12-18-9/12 yrs old) with C.D. by Tr.M. (followup 8-72 months post-operatively). Grow...
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Article
Down-regulation of gonadotropin release by the ovine fetal pituitary gland by the superagonist D-Trp6pro9NET-LRF
D-Trp6Pro9NET-LRF (Trp6-LRF) a superagonist analogue of LRF has caused suppression of gonadotropin secretion when administered chronically in animals and in humans, but has not been studied in the fetus. In 3 chr...
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Article
451A TREATMENT OF CUSHINGS DISEASE (C.D.) BY TRANSPHENOIDAL MICROADENECTOMY (Tr.M.) IN CHILDHOOD AND ADOLESCENCE
The efficacy of Tr.M. in the treatment of C. D. in children and adolescents has not been assessed. We treated 7 patients (7-6/12 to 18-9/12 years old) with C.D. before epiphyseal fusion with Tr.M. (followup 2-...
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Article
383 CORTICOSTEROID BINDING GLOBULIN (CBG) IN FETAL AND NEWBORN SHEEP
To examine the ontogeny and regulation of CBG in the perinatal period, we determined plasma cortisol binding capacity using a charcoal absorption assay. CBG capacity increased progressively from 1.6 μg/dl at 7...
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Article
284 ANTIBODIES TO LUTEINIZING HORMONE IN A PATIENT TREATED WITH GROWTH HORMONE
Many clinical grade preparations of hGH (human growth hormone) are contaminated with hLH and hFSH. However, no evidence of a clinical effect of such contamination has been described. We report the development ...
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Article
315 ACTH-PRODUCING INTRACRANIAL TUMOR IN AN INFANT
ACTH-producing brain tumors in infancy are rare. An 8 month male was evaluated for a 4 month history of profound obesity, acne, moon-facies, hypertension, and hirsutism. An IVP and computerized tomographic (CT...
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Article
964 FETAL PROLACTIN (PRL) AND THE RESPIRATORY DISTRESS SYNDROME (RDS)
There is a temporal relationship between plasma PRL, cortisol (F) and pulmonary surfactant production in the fetus. PRL administered to fetal rabbits is reported to increase pulmonary surfactant content. To ex...
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Article
339 THE ONTOGENY OF GONADOTROPINS AND SEX STEROIDS IN THE SHEEP FETUS
Using the chronically catheterized sheep fetus, the ontogeny of FSH, LH, testosterone (T), androstenedione (A), dehydroepian-drosterone (D), and D sulfate (DS) was studied in 84 fetuses from 70d to term (150d).
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Article
DEVELOPMENTAL PATTERN OF α SUBUNIT IN THE PREPUBERTAL AND PUBERTAL CHILD AND IN HYPERGONADOTROPIC HYPOGONADISM
Glycoprotein hormones share a common α subunit but each has a β subunit which confers biologic and immunologic specificity. α glycoprotein hormone subunit (α)is present in the adult pituitary in concentrations gr...
