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  1. No Access

    Article

    Extracellular matrix loss in chondrocytes after exposure to interleukin-1β in NADPH oxidase-dependent manner

    Osteoarthritis is a degenerative joint disease caused by excessive death of chondrocytes and loss of the extracellular matrix (ECM) in articular cartilage. We previously reported that reactive oxygen species (...

    Sakie Funato, Rika Yasuhara, Kentaro Yoshimura, Yoichi Miyamoto… in Cell and Tissue Research (2017)

  2. Article

    Open Access

    Effects of antibody to receptor activator of nuclear factor κ-B ligand on inflammation and cartilage degradation in collagen antibody-induced arthritis in mice

    Rheumatoid arthritis (RA) is an inflammatory disease that leads to destruction of both articular cartilage and bone tissues. In rheumatic joints, synoviocytes and T-lymphocytes as well as bone cells produce th...

    Sakie Funato, Akihiro Matsunaga, Koei Oh… in Journal of Negative Results in BioMedicine (2014)

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  3. No Access

    Article

    BMP2 Differentially Regulates the Expression of Gremlin1 and Gremlin2, the Negative Regulators of BMP Function, During Osteoblast Differentiation

    Bone morphogenetic proteins (BMPs) control the expressions of many genes involved in bone formation. On the basis of our hypothesis that BMP2 stimulation-regulated gene expression plays a critical role in oste...

    Dai Suzuki, Atsushi Yamada, Ryo Aizawa, Sakie Funato… in Calcified Tissue International (2012)