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  1. Article

    Open Access

    BABAR: an R package to simplify the normalisation of common reference design microarray-based transcriptomic datasets

    The development of DNA microarrays has facilitated the generation of hundreds of thousands of transcriptomic datasets. The use of a common reference microarray design allows existing transcriptomic data to be ...

    Mark J Alston, John Seers, Jay CD Hinton, Sacha Lucchini in BMC Bioinformatics (2010)

  2. Article

    Open Access

    The transcriptional programme of Salmonella enterica serovar Typhimurium reveals a key role for tryptophan metabolism in biofilms

    Biofilm formation enhances the capacity of pathogenic Salmonella bacteria to survive stresses that are commonly encountered within food processing and during host infection. The persistence of Salmonella within t...

    Shea Hamilton, Roy JM Bongaerts, Francis Mulholland, Brett Cochrane in BMC Genomics (2009)

  3. No Access

    Article

    Coding sequence targeting by MicC RNA reveals bacterial mRNA silencing downstream of translational initiation

    Bacterial small RNAs are generally thought to repress mRNAs at the level of translational initiation by binding in the 5′ untranslated region. Salmonella typhimurium MicC is now shown to target the ompD mRNA codi...

    Verena Pfeiffer, Kai Papenfort, Sacha Lucchini in Nature Structural & Molecular Biology (2009)

  4. Article

    Open Access

    A short-oligonucleotide microarray that allows improved detection of gastrointestinal tract microbial communities

    The human gastrointestinal (GI) tract contains a diverse collection of bacteria, most of which are unculturable by conventional microbiological methods. Increasingly molecular profiling techniques are being em...

    Carl R Harrington, Sacha Lucchini, Karyn P Ridgway, Udo Wegmann in BMC Microbiology (2008)

  5. Article

    Open Access

    A global view of Staphylococcus aureus whole genome expression upon internalization in human epithelial cells

    Staphylococcus aureus, a leading cause of chronic or acute infections, is traditionally considered an extracellular pathogen despite repeated reports of S. aureus internalization by a variety of non-myeloid cells...

    Christian Garzoni, Patrice Francois, Antoine Huyghe, Sabine Couzinet in BMC Genomics (2007)

  6. No Access

    Article

    Comparative genomics of phages and prophages in lactic acid bacteria

    Comparative phage genomics has become possible due to the availability of more than 100 complete phage genome sequences and the development of powerful bioinformatics tools. This technology, profiting from cla...

    Frank Desiere, Sacha Lucchini, Carlos Canchaya, Marco Ventura in Antonie van Leeuwenhoek (2002)

  7. No Access

    Chapter

    Comparative genomics of phages and prophages in lactic acid bacteria

    Comparative phage genomics has become possible due to the availability of more than 100 complete phage genome sequences and the development of powerful bioinformatics tools. This technology, profiting from cla...

    Frank Desiere, Sacha Lucchini in Lactic Acid Bacteria: Genetics, Metabolism… (2002)

  8. No Access

    Article

    Molecular Ecology and Evolution of Streptococcus thermophilus Bacteriophages—a Review

    Bacteriophages attacking Streptococcus thermophilus, a lactic acid bacterium used in milk fermentation, are a threat to the dairy industry. These small isometric-headed phages possess double-stranded DNA genom...

    Harald Brüssow, Anne Bruttin, Frank Desiere, Sacha Lucchini, Sophie Foley in Virus Genes (1998)