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Article
Open AccessStructural basis of the Meinwald rearrangement catalysed by styrene oxide isomerase
Membrane-bound styrene oxide isomerase (SOI) catalyses the Meinwald rearrangement—a Lewis-acid-catalysed isomerization of an epoxide to a carbonyl compound—and has been used in single and cascade reactions. Ho...
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Article
Serine administration as a novel prophylactic approach to reduce the severity of acute pancreatitis during diabetes in mice
Compared with the general population, individuals with diabetes have a higher risk of develo** severe acute pancreatitis, a highly debilitating and potentially lethal inflammation of the exocrine pancreas. I...
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Article
Open AccessThe extracellular gate shapes the energy profile of an ABC exporter
ABC exporters harness the energy of ATP to pump substrates across membranes. Extracellular gate opening and closure are key steps of the transport cycle, but the underlying mechanism is poorly understood. Here...
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Article
Open AccessHighly modified and immunoactive N-glycans of the canine heartworm
The canine heartworm (Dirofilaria immitis) is a mosquito-borne parasitic nematode whose range is extending due to climate change. In a four-dimensional analysis involving HPLC, MALDI-TOF–MS and MS/MS in combinati...
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Article
Open AccessInhibition of Haemonchus contortus larval development by fungal lectins
Lectins are carbohydrate-binding proteins that are involved in fundamental intra- and extracellular biological processes. They occur ubiquitously in nature and are especially abundant in plants and fungi. It h...
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Article
Polymerase chain reaction for detection of patent infections of Echinococcus granulosus (“sheep strain”) in naturally infected dogs
Polymerase chain reaction (PCR) for the identification of eggs of the tapeworm Echinococcus granulosus (“sheep strain”) was evaluated with primers derived from mitochondrial sequences. Specificity of these primer...
