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Complete elimination of established neuroblastoma by synergistic action of γ-irradiation and DCs treated with rSeV expressing interferon-β gene
Dendritic cell (DC)-based immunotherapy has been investigated as a new therapeutic approach to intractable neuroblastomas; however, only limited clinical effect has been reported. To overcome the relatively lo...
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Article
Impact of deletion of envelope-related genes of recombinant Sendai viruses on immune responses following pulmonary gene transfer of neonatal mice
We demonstrated previously that the additive-type recombinant Sendai virus (rSeV) is highly efficient for use in pulmonary gene transfer; however, rSeV exhibits inflammatory responses. To overcome this problem...
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Article
A case of an inflammatory myofibroblastic tumor in the lung which expressed TPM3–ALK gene fusion
We herein describe a 4-year-old boy who after being treated for pneumonia showed an abnormal shadow at the hilus of the right lung on chest X-rays with continued inflammatory findings in his laboratory data. C...
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Open AccessMYCN gene amplification is a powerful prognostic factor even in infantile neuroblastoma detected by mass screening
MYCN is the most powerful prognostic factor in cases of older children. However, how MYCN is related to the prognosis of infantile cases is not clear. A mass screening program was carried out by measuring urinary...
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Article
Endoscopic diverticulotomy for symptomatic pediatric esophageal diverticula
There have so far been few reports on esophageal diverticulum in children. We experienced two symptomatic pediatric cases with esophageal diverticulum. Our cases manifested high fever and dysphagia with chest ...
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Article
Open AccessHigh expression of telomerase is an independent prognostic indicator of poor outcome in hepatoblastoma
Telomerase, an enzyme related with cellular immortality, has been extensively studied in many kinds of malignant tumours for clinical diagnostic or prognostic utilities. Telomerase activity is mainly regulated...
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Article
Universal distribution of c-kit-positive cells in different types of Hirschsprung's disease
Interstitial cells of Cajal (ICCs) have been reported to play the role of a pacemaker in regulating bowel motility. The relationship between neurons and ICCs, however, remains unclear. Hirschsprung's disease (...
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Effects of omega-3 fatty acids in rat allogenic small intestinal transplantation
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Article
Open AccessExperience with International Neuroblastoma Staging System and Pathology Classification
The International Neuroblastoma Staging System and Pathology Classification were proposed in 1988 and in 1999, respectively, but their clinical value has not yet been fully studied in new patients. Six hundred...
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Article
Funnel chest: treatment strategy and follow-up
Although funnel chest is the most frequently seen deformity of the anterior chest wall in children, there is still considerable controversy regarding three major aspects, namely, the frequency of such deformi...
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Article
The biological effect of phthalate esters on transabdominal migration of the testis in fetal rats in comparison with the antiandrogen flutamide
Phthalate esters are commonly used as plasticizers for polyvinyl chloride and are known to be hormone-disrupting chemicals. We previously reported that mono-n-butyl phthalate (MBP) administered to rat fetuses in...
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Article
The formation of the chick ileal muscle layers as revealed by α-smooth muscle actin immunohistochemistry
The genesis of intestinal smooth muscle layers was immunohistochemically investigated by use of an antibody to α-smooth muscle actin (α-SMA) in the develo** chick ileum. Myoblast cells positive for α-SMA wer...
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Article
Helicobacter pylori infection in postoperative patients with biliary atresia A benign colonization?
The prevalence of Helicobacter pylori infection in postoperative patients with biliary atresia (BA) was investigated in relation to esophageal varices, portal-hypertensive gastropathy (PHG), and peptic ulcer dis...
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Article
Expression of Clara cell 10-kDa protein (CC10) in congenital diaphragmatic hernia
Clara cell 10 kDa protein (CC10) has been thought to be fairly specific to Clara cells and a major secretory protein that is both synthesized and released from Clara cells. In the present study, morphometric ...
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Article
Prenatal ultrasonograms showing a reduced amniotic cavity in a patient with
Multiple genitourinary, anorectal, and limb anomalies are described in association with the presence of intrauterine compression in a male newborn. Bilateral hydronephrosis, and imperforate anus with a rectour...
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Article
CT manifestations of pediatric intrathoracic desmoid tumors
We describe the CT findings in two pediatric cases of intrathoracic desmoid tumor arising from the chest wall. In both cases, CT showed heterogeneously enhanced intrathoracic masses with destruction of the ribs.
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Article
The significance of cytological examination on reperfusion in rat small intestinal transplantation
We examined the cytology of the exudate in preserved intestinal grafts on reperfusion and compared it with the histological findings in rat small intestinal transplantation. The jejunal graft was harvested fro...
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Postoperative MRI evaluation of anorectal malformations with clinical correlation
Sixteen postoperative patients with anorectal malformation were evaluated by MRI, and the results compared with the clinical assessment. Patients were classified into three groups — good (group 1,n=10), fair (gro...
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Article
Verapamil attenuates postischemic oxidative injury in the rat liver
We assessed the effects of the calcium channel blocker verapamil on postischemic oxidative injury in the rat liver. In the untreated rats, the values of tissue lipid peroxidation products (thiobarbituric acid-...
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Effect of verapamil on conversion of xanthine dehydrogenase to oxidase in ischemic rat liver
The effect of organ flushing with the calcium entry blocker verapamil on the conversion of innocent enzyme xanthine dehydrogenase (XDH) to superoxide generating enzyme xanthine oxidase (XOD) in ischemic rat li...