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Article
Knowledge, attitudes, and perceived barriers towards genetic testing across three rural Illinois communities
Genetic testing is becoming more prevalent in detecting risk and guiding cancer treatment in our increasingly personalized medicine model. However, few studies have examined underserved populations’ perception...
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Article
Open AccessOncogenic CXCL10 signalling drives metastasis development and poor clinical outcome
The CXCL10/CXCR3 signalling mediates paracrine interactions between tumour and stromal cells that govern leukocyte trafficking and angiogenesis. Emerging data implicate noncanonical CXCL10/CXCR3 signalling in ...
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Article
In tumors Salmonella migrate away from vasculature toward the transition zone and induce apoptosis
Motile bacteria can overcome diffusion resistances that substantially reduce the efficacy of standard cancer therapies. Many reports have also recently described the ability of Salmonella to deliver therapeutic m...
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Article
Open AccessTumour-targeted delivery of TRAIL using Salmonella typhimurium enhances breast cancer survival in mice
An effective cancer therapeutic must selectively target tumours with minimal systemic toxicity. Expression of a cytotoxic protein using Salmonella typhimurium would enable spatial and temporal control of delivery...