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Article
Open AccessHigh-throughput sequencing of nodal marginal zone lymphomas identifies recurrent BRAF mutations
Nodal marginal zone lymphoma (NMZL) is a rare small B-cell lymphoma lacking disease-defining phenotype and precise diagnostic markers. To better understand the mutational landscape of NMZL, particularly in com...
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Article
Distinct genetic evolution patterns of relapsing diffuse large B-cell lymphoma revealed by genome-wide copy number aberration and targeted sequencing analysis
Recurrences of diffuse large B-cell lymphomas (DLBCL) result in significant morbidity and mortality, but their underlying genetic and biological mechanisms are unclear. Clonal relationship in DLBCL relapses so...
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Follicular lymphoma transformation into histiocytic sarcoma: indications for a common neoplastic progenitor
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Article
Open AccessA role for eukaryotic initiation factor 4B overexpression in the pathogenesis of diffuse large B-cell lymphoma
Dysregulated expression of factors that control protein synthesis is associated with poor prognosis of many cancers, but the underlying mechanisms are not well defined. Analysis of the diffuse large B-cell lym...
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Article
MCL1 is deregulated in subgroups of diffuse large B-cell lymphoma
Myeloid cell leukemia-1 (MCL1) is an anti-apoptotic member of the BCL2 family that is deregulated in various solid and hematological malignancies. However, its role in the molecular pathogenesis of diffuse lar...
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Paracrine promotion of tumor development by the TNF ligand APRIL in Hodgkin's Disease