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  1. No Access

    Article

    scAAV-mediated gene transfer of interleukin-1-receptor antagonist to synovium and articular cartilage in large mammalian joints

    With the long-term goal of develo** a gene-based treatment for osteoarthritis (OA), we performed studies to evaluate the equine joint as a model for adeno-associated virus (AAV)-mediated gene transfer to lar...

    R S Watson, T A Broome, P P Levings, B L Rice, J D Kay, A D Smith, E Gouze… in Gene Therapy (2013)

  2. No Access

    Article

    Progress and Prospects: genetic treatments for disorders of bones and joints

    Gene therapies directed toward the treatment of arthritis and tissue repair continue to be the most active areas of research for bone and joint diseases. In the past 2 years, two trials in rheumatoid arthritis...

    C H Evans, S C Ghivizzani, P D Robbins in Gene Therapy (2009)

  3. No Access

    Article

    A simple, lanthanide-based method to enhance the transduction efficiency of adenovirus vectors

    Based upon the powerful bridging and charge-masking properties of lanthanide cations (Ln3+), we have investigated their use to improve the transduction efficiency of adenovirus vectors. Using a luciferase marker ...

    G D Palmer, M J Stoddart, E Gouze, J-N Gouze, S C Ghivizzani, R M Porter… in Gene Therapy (2008)

  4. No Access

    Article

    Intra-articular adenoviral-mediated gene transfer of trail induces apoptosis of arthritic rabbit synovium

    Rheumatoid arthritis (RA) is an inflammatory autoimmune disease that primarily affects joints. In rheumatoid joints there is extensive synovial proliferation with diseased synovium becoming highly aggressive, ...

    Q Yao, S Wang, A Gambotto, J C Glorioso, C H Evans, P D Robbins… in Gene Therapy (2003)

  5. No Access

    Article

    Gene Therapy for Autoimmune Disorders

    Although many autoimmune disorders do not have a strong genetic basis, their treatment may nevertheless be improved by gene therapies. Most strategies seek to transfer genes encoding immunomodulatory products ...

    C. H. Evans, S. C. Ghivizzani, T. J. Oligino… in Journal of Clinical Immunology (2000)

  6. No Access

    Article

    Genetic enhancement of fracture repair: healing of an experimental segmental defect by adenoviral transfer of the BMP-2 gene

    This study evaluated the ability of gene transfer to enhance bone healing. Segmental defects were created surgically in the femora of New Zealand white rabbits. First generation adenoviruses were used as vecto...

    A W A Baltzer, C Lattermann, J D Whalen, P Wooley, K Weiss, M Grimm… in Gene Therapy (2000)

  7. No Access

    Article

    Intra-articular delivery of a herpes simplex virus IL-1Ra gene vector reduces inflammation in a rabbit model of arthritis

    To evaluate the use of HSV-based vectors for arthritis gene therapy we have constructed a first-generation, ICP4 deficient, replication defective herpes simplex virus (HSV) vector (S/0−) and a second-generatio...

    T Oligino, S C Ghivizzani, D Wolfe, E R Lechman, D Krisky, Z Mi, C H Evans… in Gene Therapy (1999)

  8. No Access

    Chapter

    Development of a Gene Therapy for Arthritis

    Over 30 million Americans suffer at least one form of the various types of arthritis, making it the most prevalent pathologic condition among those over 65 years of age. Of the arthritides, rheumatoid arthriti...

    P. D. Robbins, S. C. Ghivizzani, R. Kang… in Interdisciplinary Approaches to Gene Thera… (1997)